Is Rapamycin Dead?

Subscribe to our channel: https://www.youtube.com/@mkaeberlein Rapamycin has been called the most promising longevity drug ever discovered—and recently, some have claimed it's also one of the biggest disappointments. So which is it? In this deep dive, I separate evidence from hype and ask a simple question: Is rapamycin actually dead as a longevity intervention, or is the science stronger than ever? We explore what decades of research really tell us, from the landmark mouse lifespan studies that transformed aging biology to the latest clinical trials in humans and companion dogs. Along the way, I address many of the most common criticisms of rapamycin, discuss recent studies that have been widely misinterpreted, and explain why anecdotes and influencer opinions should never outweigh rigorous scientific evidence. Topics covered include: • Why rapamycin remains the most robust and reproducible longevity intervention in laboratory animals • What we know—and don't know—about rapamycin in healthy humans • Safety, dosing, and common misconceptions • Effects on immune function, brain aging, heart health, oral health, ovarian aging, muscle, and inflammation • What recent human clinical trials actually found • Why definitive longevity trials have been so difficult to perform • The future of rapamycin research, including ongoing clinical trials Rapamycin is not a miracle drug, and it is not proven to extend human lifespan. But after reviewing the totality of the evidence, I explain why I believe it remains the strongest scientific candidate we currently have for targeting the biology of aging. If you're interested in evidence-based longevity science—not hype—this lecture is for you. Related videos: ▶️ Veronica Galvan: https://youtu.be/TWc5gvhPkCc ▶️ Steve Austad: https://youtu.be/UxFnkZ_mRVM ▶️ Bonnie LaFleur: https://youtu.be/JxpZtytGs00 ▶️ Dog Aging Project: https://youtu.be/8J6E5SWw8Gk If you enjoy evidence-based discussions about aging biology, longevity medicine, and the latest research, please consider subscribing to Longevity Science and let me know your thoughts in the comments. #Longevity #Rapamycin #Sirolimus #HealthyAging #Healthspan #Aging #Geroscience #mTOR #LongevityScience #BiologicalAging 00:00 Introduction – Is Rapamycin Dead? 02:00 The Longevity Signal-to-Noise Problem 04:24 What Is Rapamycin? 07:45 Why Rapamycin Changed Aging Research Forever 10:10 Can Rapamycin Reverse Aspects of Aging? 12:38 Restoring Heart Function in Aging Mice 18:09 Rejuvenating the Aging Immune System 23:30 Reversing Periodontal Disease 27:02 Can Short-Term Rapamycin Extend Lifespan? 30:03 Why the Mouse Data Matter 35:27 What We've Learned from Dogs 43:52 Human Evidence: What Do We Actually Know? 45:35 Safety, Side Effects & Off-Label Dosing 49:23 Alan Green and the Rapamycin Movement 52:05 Clinical Trials: Immune Function 57:31 Off-Label Human Data 01:02:53 Rapamycin and Oral Health 01:03:39 Brain Aging & Alzheimer's Disease 01:07:23 Ovarian Aging & Fertility 01:09:16 Chronic Fatigue Syndrome & Long COVID 01:11:56 Rapamycin, Muscle & Ex DISCLAIMER: The information provided on this channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find me: Instagram: https://www.instagram.com/mkaeberlein/ LinkedIn: https://www.linkedin.com/in/mkaeberlein/ Twitter: https://twitter.com/mkaeberlein Facebook: https://www.facebook.com/matt.kaeberlein/