Biohacking Aging: Everything You Need To Know About Rapamycin

Rapamycin might be the most powerful longevity drug ever discovered — a molecule that slows aging by tricking your cells into thinking they’re fasting. In this video, I break down how rapamycin actually works, what the ITP studies found, and why it’s one of the only drugs that consistently extends lifespan in mammals. We’ll look at the human trials, side effects, and mechanism of action. Connect with Me: Subscribe to this channel: https://www.youtube.com/@DarkModeBiohacking?sub_confirmation=1 Discord: https://discord.gg/4WH9bxv2 X: https://x.com/darkmodebio Chapters: 00:00 Intro 00:39 1 – Why Did Nature Make This? 01:24 2 – How Does it Work? 02:42 3 – What Do the Studies Say? References: Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update 10.1016/j.exger.2023.112166 Rapamycin for longevity: the pros, the cons, and future perspectives 10.3389/fragi.2025.1628187 What is the clinical evidence to support off-label rapamycin therapy in healthy adults? 10.18632/aging.206300 Sirolimus and mTOR Inhibitors: A Review of Side Effects and Specific Management in Solid Organ Transplantation 10.1007/s40264-019-00810-9 Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials 10.1016/s2666-7568(21)00062-3 Hallmarks of aging: An expanding universe 10.1016/j.cell.2022.11.001 Targeting ageing with rapamycin and its derivatives in humans: a systematic review 10.1016/s2666-7568(23)00258-1 Blazing a trail for the clinical use of rapamycin as a geroprotecTOR 10.1007/s11357-023-00935-x Evaluation of off-label rapamycin use to promote healthspan in 333 adults 10.1007/s11357-023-00818-1 Sex as a major determinant of pro-longevity drug efficacy: a review of two decades of the NIA Interventions Testing Program 10.1093/gerona/glaf138 Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis 10.1111/acel.70131 The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan 10.1038/s43587-025-00876-4 Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension 10.1016/j.molmet.2024.101902 The origin story of rapamycin: systemic bias in biomedical research and cold war politics 10.1091/mbc.E22-08-0377 A treasure from a barren island: the discovery of rapamycin 10.1093/ckj/sfac116 A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08490-2 Brad Stanfield on Rapamycin Longevity Series | Rapamycin, mTOR and the importance of muscle in life https://www.youtube.com/watch?v=80IaqThlf0A Matt Kaeberlein on Rapamycin Longevity Series | Lessons learned from 2 decades of Rapamycin research https://www.youtube.com/watch?v=PFKuxj5T6GA Alan Green on Rapamycin Longevity Series | Lessons learned from over 1200 patients https://www.youtube.com/watch?v=zWJQecgNloU Joan Mannick on Rapamycin Longevity Series | Turning down mTOR to young levels may be good for aging https://www.youtube.com/watch?v=f1b4sxLQD08 Discovering the keys to a healthy lifespan https://dogagingproject.org/ I refuse to let you down https://x.com/BradStanfieldMD/status/1977148137182843125 Combo of cancer therapy drugs increases mice lifespan by 30% — but anti-aging benefits in humans remain unknown https://www.livescience.com/health/ageing/combo-of-cancer-therapy-drugs-increases-mice-lifespan-by-30-percent-but-anti-aging-benefits-in-humans-remain-unknown I Refuse to Let You Down https://www.youtube.com/@DrBradStanfield #Rapamycin #Longevity #mTOR