The #1 Supplement That Actually Reverses Your Biological Age

A new real-world observational study from the National University of Singapore evaluated 4,260 health-optimized individuals to test if popular longevity supplements move the needle on epigenetic biological age. Out of 84 compounds analyzed, delayed-release calcium alpha-ketoglutarate (dAKG) demonstrated the strongest correlation with a reduced biological age residual. Learn how delivery mechanism, cellular TET enzymes, and epigenetic methylation factors drive this biological signal. Some links are affiliate links so we will earn a commission when they are used to purchase products. 🧬 SUPPORT THE CHANNEL & LONGEVITY PARTNERS If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *Qualia* (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd Senolytic https://bit.ly/4jlaibe *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *AX3 Life* (20% off: MODERN20) https://ax3.life/MODERN20 - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg ~~~~~~~~~~~~~~ Can longevity supplements provide biological benefits if your diet, sleep, and lifestyle are already optimized? A study published in Aging Cell by researchers at the National University of Singapore analyzed 4,260 health enthusiasts using a 9-CpG DNA methylation clock developed with TrueMe. Evaluating 84 distinct supplements, the team discovered that a delayed-release calcium alpha-ketoglutarate (dAKG) formulation was significantly associated with a 1.8-year lower biological age residual. Standard non-delayed AKG failed to produce a statistically significant benefit, highlighting the necessity of effective GI delivery. Mechanistically, AKG acts as an essential substrate for TET enzymes, driving active DNA demethylation to counteract epigenetic drift. While observational design and author affiliations require careful objective evaluation, the data reveals a compelling signal for targeted metabolic supplementation. 📚 Chapters 0:00 – Introduction: Do Supplements Still Help an Optimized Lifestyle? 0:40 – The NUS Study: Tracking 4,260 Health Enthusiasts 2:23 – Methodology: The 9-CpG Epigenetic Clock 3:03 – The Winner: Delayed-Release Calcium AKG (Rejuvenant) 4:22 – Why It Works: AKG, TET Enzymes & Epigenetic Drift 7:03 – Limitations & Conflict of Interest: Is the Data Still Convincing? 🌐Scientific Reference Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals https://onlinelibrary.wiley.com/doi/10.1111/acel.70517 *************************************** Disclaimer: This video is for educational and informational purposes only and covers scientific research published in Aging Cell titled "Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals" (doi: 10.1111/acel.70517). This content does not constitute medical advice, diagnosis, or treatment recommendations. Always consult a qualified physician or healthcare provider before introducing new dietary supplements, altered dosages, or therapeutic protocols into your routine. ********************************************** #longevity #healthspan #AKG