Episode 17 Trick your body into thinking its fasting with Caloric Restriction Mimetics

Three years ago, I got my biological pace of aging to 0.65—aging at two-thirds speed—while spending less than $150/month vs Bryan Johnson's $2M/year. After a supplement mistake pushed my pace to 0.76, I'm documenting this one-year food-based journey back. Episode 26 reveals if it worked. CONNECT WITH ME Study notes for each episode: https://www.juliegibsonclark.com/contact-6 If this changed how you think about supplements, give it a thumbs up RESOURCES: - Lead free tested turmeric: https://amzn.to/4bF58oG - My Amazon store for supplements, kitchen equipment and more: https://www.amazon.com/shop/juliegibsonclark?ref_=cm_sw_r_cp_ud_aipsfshop_X5G2EH888RZTSVRQ5VFD_1 - The one longevity supplement I use: novos.sjv.io/55Gmro Use 5OFFJGC for $5 off - Yu Tea Sencha (used in glaze): Use JULSGC for 20% off. https://www.yutea.com?bg_ref=hCuNY7zorN - Full recipe: Golden Turmeric Chicken with Sencha-Citrus Glaze: https://drive.google.com/file/d/1yFczySTlC-5S9VYLi6FZzyQ3pvGA1XW6/view?usp=sharing TIMESTAMPS 0:00 - Intro 2:00 - CR Mimetics 101: Getting the Signal Without the Deprivation 7:23 - Paper 1: The CRM Landscape (Ingram & Roth) 14:38 - Paper 2: The Mechanism — Protein Deacetylation & Autophagy (Madeo et al.) 23:20 - Connecting the Research 25:45 - Kitchen Application: Golden Turmeric Chicken with Sencha-Citrus Glaze 44:22 - Wrap-Up: Limitation, Personal Protocol and next episode preview KEY TAKEAWAYS ✓ The most powerful longevity intervention ever studied — and why almost no one can actually do it ✓ How certain foods send the same cellular signal without the deprivation ✓ Why combining compounds through food may be fundamentally different from taking them as supplements (my data is the cautionary example) ✓ The 2025 update on a supplement half the longevity world is taking — you may want to hear this before your next order ✓ The one ingredient you're probably leaving out of your turmeric that makes or breaks whether it works ✓ A dinner that activates four distinct longevity pathways — and actually looks like something you'd want to eat KEY VOCABULARY DEFINED IN EPISODE Protein Acetylation — A process where the body attaches a small chemical tag (called an acetyl group) to a protein. Think of it like putting a sticky note on a protein that changes how it behaves—turning certain functions up, down, on, or off. Deacetylation — The opposite of acetylation. The body removes that chemical tag from a protein, which can change the protein's activity again. It's like taking the sticky note off. EP300 — A protein that helps add acetyl groups to other proteins and genes. You can think of EP300 as a "switch operator" that helps turn certain genes and cellular activities on. Acetyl-CoA (AcCoA) — A molecule that acts like a delivery truck carrying acetyl groups around the cell. It provides the raw material needed for acetylation and is also important for producing energy. SIRT1 — A protein that removes acetyl groups from other proteins (deacetylation). Often called a "longevity" or "cell maintenance" protein because it helps cells respond to stress, repair damage, and regulate metabolism. Resveratrol — A natural compound found in red grapes, red wine, peanuts, and some berries. It is known for potentially activating SIRT1 and is often studied for its possible anti-aging and health benefits. Piperine — A natural compound found in black pepper. Its main claim to fame is helping the body absorb certain nutrients and supplements more effectively, making them more available to the body. Upstream Targeting — Addressing a problem at its source rather than dealing with the downstream effects. For example, fixing a leaky pipe instead of repeatedly mopping up the water on the floor. In biology, it means influencing an earlier step in a pathway so that many later effects can be changed at once. SAFETY NOTES ⚠️ Turmeric interacts with blood thinners and certain medications — consult your doctor ⚠️ High-dose turmeric can cause digestive upset and gallbladder contractions ⚠️ Resveratrol supplements have not been validated as a lifespan intervention — discussed in episode ⚠️ Not a substitute for medical advice; consult your healthcare provider before significant dietary changes RESEARCH PAPERS • Ingram, D.K., Roth, G.S. (2014). "Calorie restriction mimetics: Can you have your cake and eat it, too?" Ageing Research Reviews. DOI: 10.1016/j.arr.2014.11.005 • Madeo, F., Carmona-Gutierrez, D., Hofer, S.J., Kroemer, G. (2019). "Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential." Cell Metabolism, 29, 592–610. DOI: 10.1016/j.cmet.2019.01.018 NEXT: EPISODE 18 — KETOSIS Your body has a second fuel system. Next episode: the longevity research on ketosis — and what a food-based protocol looks like. DISCLAIMER: I'm not a doctor or nutritionist. Consult your healthcare provider before making significant dietary changes.