This Doctor Proved Aging Can Be Stopped Before It Starts

Can aging be stopped before it starts? Dr. Nir Barzilai reveals the science-backed longevity protocol to prevent age-related diseases and reverse your biological clock. Dr. Mark Hyman is joined by Dr. Nir Barzilai, a leading geroscientist and the founder of the Einstein Nathan Shock Center. Together, they break down the critical difference between chronological age and the actual biology of aging, revealing how we can target aging at its root source to dramatically extend our clinical health span. Dr. Barzilai shares his personal longevity routine—including intermittent fasting, strict daily exercise, and sleep habits—while diving deep into his groundbreaking research on "SuperAgers." Discover why certain genetic traits, like surprisingly low IGF-1 (growth hormone) levels, protect centenarians from chronic disease, and how everyday people can mimic these effects. We also explore the controversial truth about metformin, the highly anticipated TAME trial, and why simply chasing the newest peptides or taking 100-supplement stacks might be doing more harm than good. If you want to understand the future of evidence-based longevity medicine without the biohacking hype, this conversation is for you. #Longevity #AntiAging #Metformin #DrMarkHyman #SuperAgers Get my FREE guide 3 Steps to Reverse Aging when you sign up for my weekly health picks 👉 https://bit.ly/IncreaseHealthspan View the Show Notes For This Episode: https://bit.ly/ep-852 This episode is brought to you by Sunlighten, Cozy Earth, BiOptimizers, and Fatty 15. For a limited time, you can save up to $600 on a Sunlighten infrared sauna. Just go to https://sunlighten.com/mark-hyman and mention my name. Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to https://CozyEarth.com and use code DRHYMAN. Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit https://bioptimizers.com/hyman and use code HYMAN10 to save 10% and get a free gift with purchase. Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit https://Fatty15.com and use code DRHYMAN10 to get started. Learn more about the Longevity Genes Project: https://www.einsteinmed.edu/centers/aging/longevity-genes-project/ Learn more about the TAME Trial: https://www.afar.org/tame-trial Get a copy of Age Later: Health Span, Life Span, and the New Science of Longevity: https://www.amazon.com/Age-Later-Healthiest-Sharpest-Centenarians/dp/1250230853 (0:00) Introduction: Biology of aging, Dr. Barzilai's longevity protocol, and lifestyle factors (3:01) Metformin, longevity doctors, and synchronizing aging research (5:06) Inspiration from Dr. Barzilai's grandfather (7:02) Biological vs. chronological age in patients (8:43) Unified theory of aging, hallmarks, and their hierarchy (14:11) Interconnected biological pathways and nutrient sensing (18:54) Complexity, redundancy, and practical microbiome research (21:15) Biomarkers and diagnosing diseases (22:15) Billionaire investments and the centenarian study (24:09) Economic and healthspan benefits from centenarian research (27:25) Genetics, protective genes, and growth hormones in aging (36:35) IGF-1, HDL, and APOC3 roles in longevity (45:35) MDIs and their significance (49:23) Peptides: promise and safety concerns (53:23) Metformin: impact, history, and TAME trial (1:03:10) Mechanisms, benefits, and critiques of metformin (1:15:57) Metformin's impact on COVID-19 and the microbiome (1:20:42) Lifestyle interventions vs. metformin for diabetes prevention (1:24:37) Metformin for healthy individuals and natural AMPK regulators (1:29:12) Geroprotective drugs and future research projects (1:37:20) The future of biomarkers in aging research