The Trial of Epigenetic Aging Clocks ⏰: ⏳ Promise, Proof & Pitfalls

⏳ Can we measure aging before disease arrives? A fascinating Nature Medicine analysis puts epigenetic aging clocks to the test. Across 51 intervention studies and 3,128 blood samples, reliable next-generation clocks—particularly DunedinPACE and PCGrimAge—were the most responsive. 🧬 Pharmacologic interventions generated especially strong signals. Responsiveness of epigenetic aging biomarkers to longevity interventions in humans.pdf But here is the clinical pearl: a clock moving backward does not yet prove that the patient will live longer or healthier. ⚠️ Responsiveness is necessary for surrogacy—but not sufficient. News and Views Putting epigenetic aging clocks on trial.pdf 🎙️ Dr RR Baliga’s Podkast for the Kurious Doc. Where Curiosity Meets Clarity!