Why Do We Age? What New Research Shows (And 5 Daily Habits That Help)

Your biological age is not a fixed number. In this video, we look at the latest research on why cells lose their instructions as we age, how biological age can rise under strain and come back down with recovery, what the first human trial of an age-reset therapy is testing, and five daily signals that human studies link with healthier aging. 0:00 The mice that aged 1:30 Part 1: Aging is lost information 3:40 Part 2: The repair crew that doesn't always come home 6:10 Part 3: The clock can run backward 9:40 Part 4: Five daily signals 16:20 Part 5: What the evidence can and cannot tell us yet 18:30 Part 6: Your bookmark protocol Research referenced in this video: Yang JH et al. Loss of epigenetic information as a cause of mammalian aging. Cell. 2023;186(2):305–326. Response to "The information theory of aging has not been tested." Cell. 2024;187(5):1103–1105. Lu Y et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020;588:124–129. Biological age is increased by stress and restored upon recovery. Cell Metabolism. 2023;35:807–820. Waziry R et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nature Aging. 2023;3:248–257. Life Biosciences. First Patient Dosed in Phase 1 Trial of ER-100 for Optic Neuropathies. June 9, 2026. Also Clinical Trials Arena, "Life Bio receives FDA approval for ER-100 clinical trial," January 2026. Efficiency of time-restricted eating and energy restriction on anthropometrics and body composition in adults: a systematic review and meta-analysis of randomized controlled trials. 2025. PMC12487415. Health effects of the time-restricted eating in adults with obesity: a systematic review and meta-analysis. 2023. PMC9979543. Effects of time-restricted eating on people with type 2 diabetes: a systematic review and meta-analysis. Diabetology & Metabolic Syndrome. 2026. Bensalem J et al. Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis. J Physiol. 2025;603(10):3019–3032. Singh S et al. High protein does not change autophagy in human peripheral blood mononuclear cells after one hour. JCI Insight. 2025;10(16):e188845. Flavonoid-rich foods and healthy ageing, analysis of the Nurses' Health Study and Health Professionals Follow-up Study. Queen's University Belfast, Edith Cowan University, and Harvard T.H. Chan School of Public Health. 2025. Li S et al. Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial. Nature Medicine. 2026. doi:10.1038/s41591-026-04239-3. Stamatakis E et al. Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality. Nature Medicine. 2022. Gordon JRS, Brieva JC. Unilateral dermatoheliosis. New England Journal of Medicine. 2012. Associations between psychological resilience and epigenetic clocks in the Health and Retirement Study. PMC10828333. Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis of randomized controlled trials. 2024. doi:10.1080/10408398.2024.2387324. Safety and metabolism-related outcomes of oral nicotinamide mononucleotide supplementation in adults: a systematic review and meta-analysis. 2026. PubMed 42514320. Li Y et al. Circulation. 2018;138:345–355. doi:10.1161/CIRCULATIONAHA.117.032047. This video is for educational purposes only and is not medical advice. Talk with your doctor before changing your diet, fasting routine, exercise, or supplements, especially if you are pregnant, take medication, have diabetes, or have a history of disordered eating. #BiologicalAge #EpigeneticAging #HealthyAging #TimeRestrictedEating #Autophagy #longevityscience Tags: biological age, epigenetic aging, epigenetic clock, how aging works, healthy aging, longevity science, autophagy, time restricted eating, intermittent fasting research, DunedinPACE, calorie restriction, flavonoids, cellular aging, aging research 2026 Ccomment: Which of the five daily signals will you start with this week? Tell me below, and I'll reply to as many as I can.