Rapamycin for Longevity: What Human Trials Suggest (And Don’t) PEARL, Immune Data, Risks | LC

In animals, rapamycin can extend lifespan. In humans, the story is… complicated. (85) We do NOT have human lifespan trials. What we do have is a growing body of human evidence around immune aging (vaccine response / antiviral signaling), “healthspan-style” outcomes, and longer-duration tolerability data in healthy adults. In this episode, we cover: - What rapamycin is (mTOR: growth vs repair signaling) - The strongest human signal so far: immune aging studies - PEARL (48 weeks): what changed, what didn’t, and why it matters - The “complicated” reality: endpoints can flip the headline (Phase 2 vs Phase 3 problem) - Real risks, real contraindications, and who should avoid it - What questions to ask a clinician if you’re still curious Important: This video is educational only and not medical advice. Rapamycin (sirolimus) is a prescription medication with meaningful risks, drug interactions, and monitoring considerations. Do not self-experiment without qualified medical supervision. Longevity Compass (KDP Book): https://amzn.to/3KmNgU8 Episode tools (Amazon affiliate links): BP Monitor https://amzn.to/4oZSt3l Pulse Oximeter https://amzn.to/4oERTHO Sleep Mask https://amzn.to/4olqg6X Blue-Blockers https://amzn.to/47wSd4x Join the conversation: If you had to pick ONE “proven human lever” for brain + heart longevity first, what would it be—BP, LDL/ApoB, sleep, strength, or social connection? — Longevity Compass 🧭 #rapamycin #mtor #longevity #healthspan #agingresearch #geroscience #immunity #lifespan #biohacking #evidencebased