Epigenetics Meets Geroscience: Unlocking New Frontiers - Michael Corley, PhD

- Presenter: Michael Corley, PhD | Weill Cornell Medicine, United States - Lecture: Epigenetics Meets Geroscience: Unlocking New Frontiers in HIV Research and Aging - Presented in Session 5: Geroscience/Frailty Meeting Name - 15th International Workshop on HIV & Aging - Subscribe to our newsletter: https://amededu.activehosted.com/f/13 - For more information, visit: https://academicmedicaleducation.com/ - Upcoming meetings: https://academicmedicaleducation.com/programs - See next year’s edition: https://academicmedicaleducation.com/meeting/16th-international-workshop-hiv-aging-2025 Meeting Description The integration of antiretroviral therapy (ART) into HIV care has dramatically extended the life expectancy of those living with HIV. This increased life expectancy is changing the demographics of the HIV epidemic. Currently, over half of individuals living with HIV are aged 50 or older. Recent estimates in Europe suggest that more than 70% of those with HIV will be over the age of 50 by 2030, accompanied by a greater burden of comorbidities and the associated treatments. In comparison to similar populations, persons with HIV, even when on effective ART, experience an excess of morbidity and mortality. Complications due to AIDS are rarely fatal for persons on ART. Instead, patients experience an early onset of aging complications, including neurocognitive decline, osteoporosis and fractures, impaired physical function, frailty, and falls. Improving the management of older adults with HIV will require a much deeper understanding of the interface between aging, HIV, associated comorbid conditions, and concurrent treatment. Additionally, research is needed to address the unique psychosocial challenges faced by this growing population. The elderly population living with HIV is particularly vulnerable to social stigma, which can lead to depression, psychological distress, compromised adherence to therapy, and overall poor treatment outcomes and quality of life. The International Workshop on Aging and HIV remains the only platform worldwide for international, cross-disciplinary scientific exchange on the increasingly recognized difficulties encountered in the clinical care and design of studies to improve the care of persons aging with HIV. The meeting gathers (basic) researchers, healthcare professionals across different disciplines, and community advocates to foster dialogue and prompt solutions that will benefit the aging population living with HIV. In addition, the workshop will also create opportunities for trainees and junior investigators to present their research, network, and learn from experts in the field.