Lifespan Boost Reprogramming and Senolytics in Drosophila

The original article: https://www.aging-us.com/article/204347/text Key-words: Aging, Senescence, Stem Cells, Lifespan Extension, Healthspan, Cellular Reprogramming, Yamanaka Factors, OKSM, Senolytics, Drosophila, Synergistic Interaction, Tissue Homeostasis, Senescence-Associated Secretory Phenotype (SASP), Intestinal Stem Cells (ISCs), Inflammation, Gompertz–Makeham Law of Mortality, Mortality Rate Doubling Time (MRDT), Initial Mortality Rate (A), Age-Acceleration Penalty, Mortality Compression, FOXO4-DRI Peptide, p53, FoxO Signaling, RNA-Seq, Transcriptional Profiles, Differentially Expressed Genes, Gene Ontology (GO), KEGG Pathway Enrichment, Metabolic Pathways, Cell Cycle, DNA Replication, Wnt Signaling, Hedgehog Signaling, mTOR Pathway, JAK/STAT Signaling, Epigenetic Aging Marks, Apoptosis, Tissue Repair, Organ Rejuvenation, Chronic Inflammation, Enterocytes (ECs), Enteroblasts (EBs), Senescence-Associated β-galactosidase (SA-β-gal), Ubiquitous Expression Model, ISC-Restricted Expression Model, Temperature Sensitive Expression System, Drug-Induced Expression Model, Genetically Manipulatable, Homeostasis, Cell Fate