Paolo Garagnani | Measuring Ageing: | Milan Longevity Summit 2026

*Paolo Garagnani, Associate Professor, University of Bologna* *Natural selection signatures of semi-supercentenerians genomes reconcile hallmark pathways of preclinical models of aging with human longevity* __ What can the genomes of exceptionally long-lived people teach us about healthy ageing? In this session from Measuring Ageing: Biomarkers, Clocks, and Predictive Tools at the Milan Longevity Summit 2026, Professor Paolo Garagnani explores how the genomes of semi-supercentenarians are revealing the biological mechanisms that promote exceptional longevity. By studying genetic signatures shaped by natural selection in individuals who have reached extreme ages in good health, researchers are uncovering pathways that align remarkably with the hallmarks of ageing identified in preclinical models. This conversation examines how human longevity genetics can validate experimental discoveries, improve our understanding of biological ageing, and accelerate the development of interventions that promote longer, healthier lives. Professor Paolo Garagnani is Associate Professor at the University of Bologna and a leading researcher in the genetics and genomics of human longevity. His work integrates genomics, bioinformatics, epigenetics, and systems biology to investigate the molecular mechanisms underlying healthy ageing and exceptional longevity, with a particular focus on centenarian and semi-supercentenarian populations. The Milan Longevity Summit brings together global leaders across science, medicine, policy, business, technology and society to rethink the future of health through a One Health perspective—recognising that the wellbeing of people, planet and economies is deeply interconnected. *Learn more about the Milan Longevity Summit:* https://www.milanlongevitysummit.org/it/speakers26/paolo-garagnani #MilanLongevitySummit #Longevity #OneHealth #PaoloGaragnani #Genomics #HumanLongevity #BiologicalAge #PrecisionMedicine #HealthyAgeing #Healthspan