What does DNA methylation tell us about aging? | Prof.Nir Eynon&Dr.Raghav Sehgal&Dr.Macsue Jacques

Is your biological age telling a different story than your birth certificate? In this episode of Decoding Longevity, we explore the fascinating world of the ageing methylome. Join hosts Raghav Sehgal and Macsue Jacques in a deep conversation with Professor Nir Eynon—Group Leader at Monash University and co-author of "Making Sense of the Ageing Methylome"—as we unravel what DNA methylation patterns reveal about how we age. 💡 Topics we cover: • What is the methylome, and how is it linked to aging? • How epigenetic clocks work—and what they can (and can't) tell us • Can exercise slow biological aging by changing methylation? • Why DNA methylation variability might explain age-related diseases • Entropy, tissue specificity, and the future of personalized aging clocks 🧬 Whether you're a longevity researcher or just longevity-curious, this episode breaks down complex science into insights that matter. 🎙️ *Based on the paper: “Making Sense of the Ageing Methylome” (Nature Reviews Genetics, 2022)* 🔗 Subscribe and follow for more episodes breaking down the science of aging 🔵 Spotify: https://open.spotify.com/episode/4jRYqjojPeAErWY56lQdns?si=r-PsNZPBSCSU43jwUdp9vQ 🔵 IG: https://www.instagram.com/decodinglongevity/ 🔵 LinkedIn: https://www.linkedin.com/company/decoding-longevity/ 🔵 Bluesky: https://bsky.app/profile/decodinglongevity.bsky.social 🔵 X: https://x.com/DcodLongevity