Geroscience: The Biology of Aging @ Oxford (Lord Florey Lecture by Sebastian A. Brunemeier)

Sebastian Aguiar Brunemeier, geroscientist and Principal at Apollo Ventures, delivers the Lord Florey Lecture at Lincoln College, Oxford in November 2018. Sebastian Aguiar was a Clarendon Scholar at Lincoln College, Oxford for his DPhil (PhD) on the biochemistry of aging. 0:10 Introduction: The Geroscience Revolution Parallels to the Antibiotic Revolution, Lord Howard Florey, and leading causes of death over the last century. 4:47 Part 1: Aging Demographics and the Silver Tsunami 9:20 Part 2: Extending 'Healthspan' Supercentenarians, the Hallmarks of Aging, Google Calico, Apollo Ventures, Juvenescence, Unity Biotech, NIH Geroscience Interest Group, squaring the mortality curve 17:00 Part 3: Geroscience Case Studies: Examples of Healthspan Extension from the Lab. Heterochronic Parabiosis, Cellular Senescence, Telomerase Gene Therapy, Caloric Restriction Mimetics, Rapamycin/Rapalogs, Metformin (TAME), Autophagy enhancement. 27:40 Part 4: Conclusion -- The Holy Grail: Harnessing Germline Immortality. Prospects for the future & Apollo Ventures portfolio companies. — The Florey Lecture is named after Lord Howard Florey, an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Sir Ernst Boris Chain and Sir Alexander Fleming for his role in the development of penicillin. Although Fleming received most of the credit for the discovery of penicillin, it was Florey who carried out the first ever clinical trials in 1941 of penicillin at the Radcliffe Infirmary in Oxford on the first patient, a postmaster from Wolvercote near Oxford. It was Florey and Chain who actually made a useful and effective drug out of penicillin, after the task had been abandoned as too difficult. Florey's discoveries, along with Alexander Fleming and Ernst Chain, are estimated to have saved over 82 million lives, and he is consequently regarded by the Australian scientific and medical community as one of its greatest figures. Sir Robert Menzies, Australia's longest-serving Prime Minister, said, "In terms of world well-being, Florey was the most important man ever born in Australia". The Lincoln College MCR Lecture series has been in existence since Michaelmas 1979.