Epigenetic Aging and Cognitive Decline in Hispanic/Latino Adults | Aging-US

Aging-US #published this #trending research paper on September 10, 2025, in Volume 17, Issue 10, entitled “Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos" by #researchers from the Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX; Institute of Gerontology and Department of Healthcare Sciences, Wayne State University, Detroit, MI; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Neurosciences, University of California San Diego, La Jolla, CA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN; Department of Psychology, San Diego State University, San Diego, CA; Department of Neurology, University of California, Sacramento, CA. @McGovernMed #aging #epigeneticclocks #dementia #cognitive #research #openaccess #openscience #peerreviewed #journal #publishing #meded DOI - https://doi.org/10.18632/aging.206317 Corresponding author - Myriam Fornage - Myriam.Fornage@uth.tmc.edu Abstract Due to the paucity of longitudinal DNA methylation data (DNAm), especially among Hispanic/Latino adults, the association between changes in epigenetic clocks over time and cognitive aging phenotypes has not been investigated. This longitudinal study included 2671 Hispanic/Latino adults (57 years; 66% women) with blood DNAm data and neurocognitive function assessed at two visits ~7 years apart. We evaluated the associations of 5 epigenetic clocks and their between-visit change with multiple measures of cognitive aging that included a global and domain-specific cognitive function score at each visit, between-visit change in global and domain-specific cognitive function score, and MCI diagnosis at visit 2 (V2). There were significant associations between greater acceleration of all clocks and lower cognitive function at each visit and MCI at V2. The strongest associations were observed for GrimAge and DunedinPACE. There were significant associations of between-visit increase in PhenoAge and GrimAge acceleration with decline in cognitive function and greater risk of MCI diagnosis at V2. Epigenetic aging is associated with lower global and domain-specific cognitive function, greater cognitive decline, and greater risk of MCI in Hispanic/Latino adults. Longitudinal assessment of change in age acceleration for second-generation clocks, GrimAge and PhenoAge may provide additional value in predicting cognitive aging beyond a single time point assessment. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206317 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, epigenetic clocks, DNA methylation, Hispanic/Latinos, cognitive function, dementia To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM