Collaboration webinar: Cellular Senescence and Senolytics in Aging and Diseases

Join us for a BioTalk webinar on cellular senescence, a hallmark of aging where cells permanently exit the cell cycle due to damage and stress. Cellular senescence, a hallmark of aging, involves the stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) often develop a pathogenic senescence-associated secretory phenotype (SASP) that promotes secondary senescence and disrupts tissue homeostasis, impairing tissue repair and regeneration. Transgenic mouse models with the capability for genetic ablation of SnCs have demonstrated their crucial role in driving aging and related diseases. Consequently, senotherapeutics have been developed to either pharmacologically eliminate SnCs (senolytics) or suppress the SASP and other senescence markers (senomorphics). Extensive preclinical studies and initial clinical trials have shown the potential benefits of senotherapeutics, leading to multiple ongoing clinical trials. In conclusion, targeting cellular senescence presents a promising therapeutic strategy for slowing aging and treating age-related diseases. This webinar is made in collaboration with GenoBioTx