NAD+ Levels: The 50% Myth vs. The Reality

ASLF Foundation Capsules: https://aslf-formulas.com/products/foundation-capsules Get them on Amazon: https://tinyurl.com/ASLFcapsules A COMPLETE LONGEVITY STACK IN ONE CAPSULE Instead of single-ingredient supplements, this stack works across multiple aging pathways at once to support energy, resilience, and long-term health. _______________________________________________________________________________________________ ABOUT THIS VIDEO: You've probably heard that NAD+ drops 50% by age 50, but a study published this year measured NAD+ in whole blood across seven groups of people, from their twenties to their late eighties, and found almost no age-related decline. In this video, we trace the "50% by 50" number back to the skin biopsy research it largely came from, look at why blood and skin may tell different stories (including how freezing blood samples appears to distort NAD+ measurements), and cover what's still well-established: CD38 and PARP enzymes consume NAD+, and both appear to become more active with age. The takeaway isn't that NAD+ decline is a myth, but that the real picture is more nuanced than one catchy number. This video is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making any changes to your diet, supplement regimen, or lifestyle. References for studies cited: 1. Trętowicz MM, et al. "Human whole-blood NAD+ levels do not vary with age or lifestyle interventions." Nature Metabolism 2026;8(6):1282–1290, published online May 14, 2026. doi:10.1038/s42255-026-01537-5. https://www.nature.com/articles/s42255-026-01537-5 PubMed 2. Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. "Age-associated changes in oxidative stress and NAD+ metabolism in human tissue." PLoS ONE 2012;7(7):e42357. https://doi.org/10.1371/journal.pone.0042357 Macquarie University Get your FREE PDF of my current Supplement stack and Anti-Aging Breakfast Smoothie Recipe here: https://aslf-formulas.com/pages/free-resources _______________________________________________________________________________________________ DISCLAIMER: The content on this channel — including videos, descriptions, links, and comments — is for educational and informational purposes only. It is not medical advice, nor is it intended to diagnose, treat, cure, or prevent any physical or psychological condition. Do not use this content to replace professional medical advice, diagnosis, or treatment. Always consult your physician or qualified healthcare provider before making any changes to your health, exercise, or nutrition routines. Philipp Karner and ASLF LLC make no guarantees about the accuracy, applicability, or completeness of any information provided. By voluntarily engaging with this content or attempting any exercise or practice shown, you assume full responsibility and risk for any resulting effects or injuries. This channel’s information may be updated, modified, or removed at any time without notice. To the fullest extent permitted by law, Philipp Karner and ASLF LLC disclaim any liability for direct, indirect, incidental, or consequential damages arising from the use or misuse of this content.