Meet Steve Horvath, the man who built the aging clock.

Steve Horvath made 5 claims worth tracking with Rhonda Patrick on FoundMyFitness. I ran the whole interview through skim and pulled the 5 biggest, tracked each one to resolution with the case on both sides, so you can judge them for yourself in minutes instead of hours. What Steve Horvath argues: • Steve Horvath argues that treating a serious chronic illness can turn back an individual's aging clock by four to five years within weeks. He states this effect is very well established by many studies worldwide, primarily for people with serious illnesses taking extreme medications, though off-the-shelf supplements also show some weaker effects. • Steve Horvath argues that fruit and vegetable intake impacts the aging clock more than exercise does. He explains that blood carotenoid levels provide an objective measure of intake, which correlated with GrimAge at minus 0.3, while exercise correlated at 0.1. • Steve Horvath states his lab's study on marmots showed their methylation clocks did not advance during hibernation. This finding supports previous studies suggesting a slowing of aging in hibernating animals, including a mouse study where reduced body temperature slowed aging clocks. The research raises questions about whether maintaining a cooler body temperature could similarly impact human aging. • The guest argues that a rigorous study demonstrated how social cumulative advantage strongly influences biological aging, as measured by methylation. The study found well-connected people carried a much lower methylation readout. This effect dwarfed the impact of stress hormones, showing social connection marks the aging clock more than stress hormones. • Guest Steve Horvath argues that specific factors can revert an old cell, like a skin cell from an 80-year-old, to a pluripotent stem cell state and push back its epigenetic age to prenatal levels. However, the problem is that these reverted cells forget their original identity, leading to potential uncontrolled division because they no longer know what they are. Chapters 00:00 Intro 01:10 Treating a serious illness turns your aging clock back four 02:29 Eating vegetables slows the aging clock more than exercise d 04:10 A hibernating marmot barely ages through the whole winter 06:28 Lifelong social advantage marks aging more than stress hormo 08:19 Four proteins can rewind an old skin cell into a stem cell