Rewriting the body's operating system for longevity

Multiple interventions for increasing longevity and addressing the core mechanisms of aging are discussed. Systemic effects of GLP-1 receptor agonists, therapeutic plasma exchange, senolytic approaches, which selectively eliminate senescent cells or disrupt their harmful secretions, and cellular reprogramming, which uses genetic manipulation to reverse cells to a more youthful, pluripotent state can now be combined, and clinical trials based on these combinations are highly likely to be successful. Furthermore, the authors introduce a burgeoning area of research—the modulation of mitotic competence—suggesting it as a promising alternative anti-aging strategy. This novel approach focuses on improving the fidelity of cell division to prevent age-associated aneuploidy and subsequent cellular senescence, offering a way to circumvent limitations found in the more established senolytic and reprogramming methods.