Cellular Senescence vs Stemness: Opposing Forces in Tissue Repair and Cancer | Aging

Aging #published a new #review on May 30, 2026, in Volume 18, titled “The love and hate relationship between cellular senescence and stemness,” by #researchers from the Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece; Intelligencia Inc, New York; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, DD19SY Dundee, UK; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M20 4GJ, UK. @nkuoa #aging #senescence #stemness #cancer #research #openaccess #openscience #PaperSpotlight #peerreview #journal #publishing #meded DOI - https://doi.org/10.18632/aging.206387 Corresponding author - Vassilis G. Gorgoulis - vgorg@med.uoa.gr Abstract Cellular senescence and stemness represent two biological entities with several opposing properties. However, both senescence and stemness serve to maintain tissue homeostasis, via different mechanisms. In adults, while non-dividing senescent cells represent a major barrier to potentially harmful cell insults, propagating stem cells are responsible for restoring the structure and functionality of damaged tissue. In this review, we highlight distinct cellular settings where an antagonistic relationship between the two states is naturally established. In contrast, major synergy between senescence and stemness is observed primarily in cancer, where inherent senescent cell features may actively promote the emergence of cancer stem cells. As the complex interplay between senescence and stemness may heavily vary between different cell types and physiological contexts, elucidating the nature of the interaction and the potential effects per case, is of considerable clinical importance. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206387 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, stemness To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM