Hallmarks of aging – time for a paradigm shift?

If you’re like me, then possibly your first introduction to the field of biogerontology is the 2013 review articles “The hallmarks of aging” by Lopez-Otin et al. This most cited review in the field of aging defines common denominators of aging in different organisms into 9 different hallmarks and is a pretty common reference point for the field. I’ve always liked the hallmarks as an introduction to the field, so much so that I described the hallmarks in some of my earliest videos. Speaking of my earliest videos, given that it’s almost my 2-year birthday on YouTube, I’d thought I’d revisit the hallmarks of aging given that there has been some recent criticism on them suggesting that maybe we should start to look beyond them. So in this video, I’ll first explain why models and paradigms are useful and then show you the different models used to explain aging (as the hallmarks is not the only model), will then look at the limitations of the hallmarks as discussed in this recent critique paper and lastly look at their solution and see if it is time for a paradigm shift. And just to let you know, I have also made this video in tandem with @LongevityScienceNews show whose video you can check out here; https://www.youtube.com/watch?v=DiufT9dvSaI TIMESTAMPS Intro - 00:00 Scientific Paradigms (Thomas Kuhn) - 01:10 Hallmarks of aging - 03:00 Hallmarks of cancer - 06:20 Issues with the hallmarks - 08:20 How to improve the hallmarks - 09:50 My thoughts - 11:00 References: The Hallmarks of Aging - https://doi.org/10.1016/j.cell.2013.05.039 Gems, D.; de Magalhães, J.P. The Hoverfly and the Wasp: A Critique of the Hallmarks of Aging as a Paradigm. Preprints 2021, 2021050310 (doi: 10.20944/preprints202105.0310.v1). The Hallmarks of Cancer - https://doi.org/10.1016/S0092-8674(00)81683-9 Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com