10 How Rapamycin Extends Healthspan and lifespan by Inhibiting Interleukin 11

Discover how Rapamycin, a medication used to prevent organ rejection, is revolutionizing anti-aging research. Learn about the connection between Rapamycin, Interleukin-11, and the mTOR pathway. Explore the potential benefits and drawbacks of this groundbreaking compound. Get ready to dive deep into the science of longevity and discover how this drug could extend your lifespan and improve your health. #Longevity #HealthyAging #Inflammation #Inflammaging #Interleukin11 #trametinib #rapamycin #metformin #MetabolicHealth #AntiAging #Healthspan #Lifespan #ERK #AMPK #mTORC1 #lysosomes #microbiome #Type_2_Diabetes #T2D #fasting #CancerTreatment #LongevityResearch #MEKPathway #KinaseInhibitors #AntiAging #MedicalResearch #ChronicInflammation #CellGrowth Please like and share this video to spread awareness! OUTLINE: 00:00 Intro 01:50 Effects on longevity 03:02 mTORC1 and mTorC2 04:26 Adverse effects of rapamycin 05:25 Outro For video licensing issues, contact: gammaoferidani@gmail.com References: [1] Deborah J W Lee, MD et al. Targeting ageing with rapamycin and its derivatives in humans: a systematic review. The Lancet (Healthy Longevity), Review Volume 5, ISSUE 2, e152-e162, February, 2024 DOI: https://doi.org/10.1016/S2666-7568(23)00258-1, https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext, accessed August 18, 2024. [2] Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006 Jan 15;20(2):174-84. doi: 10.1101/gad.1381406. PMID: 16418483; PMCID: PMC1356109. [3] Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8. PMID: 19587680; PMCID: PMC2786175. [4] Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A. Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. J Gerontol A Biol Sci Med Sci. 2015 May;70(5):577-87. doi: 10.1093/gerona/glu101. Epub 2014 Jul 19. PMID: 25038772; PMCID: PMC4400395. [5] “Rapamune Prescribing Information" (PDF). United States Food and Drug Administration. Wyeth Pharmaceuticals, Inc. May 2015. [6] Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. Hypothalamic mTOR signaling regulates food intake. Science. 2006 May 12;312(5775):927-30. doi: 10.1126/science.1124147. PMID: 16690869. [7] Kriete A, Bosl WJ, Booker G. Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses. PLoS Comput Biol. 2010 Jun 17;6(6):e1000820. doi: 10.1371/journal.pcbi.1000820. PMID: 20585546; PMCID: PMC2887462. [8] Kriete A, Bosl WJ, Booker G. Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses. PLoS Comput Biol. 2010 Jun 17;6(6):e1000820. doi: 10.1371/journal.pcbi.1000820. PMID: 20585546; PMCID: PMC2887462. [9] Magnuson B, Ekim B, Fingar DC. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J. 2012 Jan 1;441(1):1-21. doi: 10.1042/BJ20110892. PMID: 22168436. [10] Brian Magnuson, Bilgen Ekim, Diane C. Fingar; Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J 1 January 2012; 441 (1): 1–21. doi: https://doi.org/10.1042/BJ20110892 [11] Schieke SM, Phillips D, McCoy JP Jr, Aponte AM, Shen RF, Balaban RS, Finkel T. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem. 2006 Sep 15;281(37):27643-52. doi: 10.1074/jbc.M603536200. Epub 2006 Jul 17. PMID: 16847060. [12] Szwed A, Kim E, Jacinto E. Regulation and metabolic functions of mTORC1 and mTORC2. Physiol Rev. 2021 Jul 1;101(3):1371-1426. doi: 10.1152/physrev.00026.2020. Epub 2021 Feb 18. PMID: 33599151; PMCID: PMC8424549. Disclaimer: This information is intended for general knowledge and informational purposes only, and does not constitute medical advice.