Podcast description: proposed 3S framework for brain resilience and dementia risk

Subscribe to our channel: https://www.youtube.com/@mkaeberlein What can we actually do to protect our brains as we age, and how much of cognitive decline may be preventable or even reversible? In this episode of Longevity Science, I sit down with neuroscientist and physician Dr. Tommy Wood, author of The Stimulated Mind, for a wide-ranging conversation about the science of brain health, cognitive resilience, and dementia risk. Tommy introduces his “3S” framework—stimulus, support, and supply—for thinking about what the brain needs to maintain and improve function across the lifespan. We discuss why brain fog and subjective cognitive decline shouldn't simply be dismissed as normal aging; the roles of cognitive stimulation, exercise, sleep, stress, metabolic and cardiovascular health; and what the evidence actually says about supplements including creatine, magnesium, omega-3s, vitamin D, multivitamins, and lithium. We also dig into pharmaceuticals and emerging approaches, including statins and PCSK9 inhibitors, GLP-1 agonists, PDE5 inhibitors, TMS and other forms of brain stimulation, and psychedelics such as psilocybin. Perhaps most importantly, we talk about reasons for optimism. Age-specific dementia incidence has declined over recent decades, and we already know much more about maintaining cognitive function than many people realize. The challenge now is figuring out how to combine what we know into strategies that help people build a more resilient brain—and maintain it for life. Topics include: brain fog and cognitive decline, dementia prevention, neuroplasticity, sleep and stress, exercise, cardiovascular and metabolic health, supplements for brain health, creatine, lithium, GLP-1 drugs, brain stimulation, psychedelics, and the future of dementia treatment. DISCLAIMER: The information provided on this channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find me: Instagram: https://www.instagram.com/mkaeberlein/ LinkedIn: https://www.linkedin.com/in/mkaeberlein/ Twitter: https://twitter.com/mkaeberlein Facebook: https://www.facebook.com/matt.kaeberlein/ --- Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!