The 5-Day Fasting Mimicking Diet: The Longevity Science Explained

You can get most of the cellular benefits of a prolonged water fast without ever skipping a meal. The Fasting Mimicking Diet is a 5-day, calorie-restricted, plant-based protocol developed by Dr. Valter Longo at USC that triggers autophagy, stem-cell activation, and metabolic reset while still letting you eat. In this video, Dr. Trevor Turner — an interventional sports and longevity physician at Pravida Health in Buckhead, Atlanta — walks through the actual clinical trial data behind the FMD, what it changes in your body, and how to know if it makes sense for you. WHAT YOU'LL LEARN: 0:00 Why prolonged water fasting is difficult and often unsafe 1:30 What the Fasting Mimicking Diet actually is (macros, calories, structure) 3:15 The biology — autophagy, IGF-1 suppression, stem-cell activation 5:00 The Wei 2017 randomized trial (100 subjects, 3 cycles) 7:00 The Brandhorst 2015 mouse-to-human bridge study 8:45 The cancer, cardiometabolic, and cognitive markers that moved 10:15 Who FMD is good for — and who it is NOT for 12:00 How I sequence FMD with a longevity regimen at Pravida KEY TAKEAWAYS: The FMD is 5 days per cycle, ~750-1,100 kcal/day, low-protein plant-based In the Wei 2017 trial (JAMA Internal Medicine), 3 cycles reduced visceral fat, blood pressure, IGF-1, and CRP The mechanism is not just caloric restriction — it is the fasting-mimicking metabolic state FMD is contraindicated in pregnancy, active cancer treatment, type 1 diabetes, eating disorder history, and BMI below 18.5 It is an adjunct to a longevity plan, not a shortcut to weight loss ABOUT DR. TURNER: Dr. Trevor Turner, MD is an interventional sports and spine physician board-certified in PM&R. He completed a precision medicine fellowship with Wild Health and founded Pravida Health, a precision longevity practice in Buckhead, Atlanta. ABOUT PRAVIDA HEALTH: Pravida Health is a precision longevity studio in Buckhead, Atlanta offering whole genome sequencing, the Bioscope.ai digital twin platform, DEXA scans, VO2 max testing, comprehensive biomarker panels, regenerative orthobiologics, and personalized longevity planning including fasting-mimicking protocols. READ THE FULL BLOG POST: https://pravida.com/blog/fasting-mimicking-diet.html LEARN MORE: Website: https://pravida.com Membership tiers: https://pravida.com/memberships.html Book a consultation: https://pravida.com/contact.html CONNECT WITH DR. TURNER: Instagram: @pravidahealth LinkedIn: Trevor Turner, MD DISCLAIMER: This video is for educational purposes only and does not constitute medical advice. Consult your physician before beginning any fasting or dietary protocol. #FastingMimickingDiet #Prolon #Longevity #Autophagy #ValterLongo #LongevityMedicine #PravidaHealth #BuckheadAtlanta #DrTrevorTurner