Brian Kennedy on Rapamycin Master Series | Aging is the biggest risk factor for age-related diseases

Professor Brian Kennedy from the National University of Singapore is one of the world's leading researchers in the longevity field and has done longevity research for more than two decades. He is active in many different longevity companies and has been the President and CEO at Buck Institute for Research on Aging. Throughout the years he has made many different important and revolutionary longevity discoveries. Currently he is also one of the persons who is trying to move the longevity forward in a much efficient and faster way. This work he is doing in Singapore where he is leading a huge longevity research project. This unique project is something we are going to talk about in the podcast. We will also talk about his research on Rapamycin and other interesting longevity topics. 00:00 Intro 02:13 Longevity interest and research 04:07 Lifespan discovery of sir2 in yeast 06:42 Lifespan discovery of TOR (mTOR) in yeast 07:14 mTOR and calorie restriction 09:19 mTOR and mechanistic downstream effects 09:55 mTOR activation and inhibition 10:20 Problem with mTOR chronic overactivation 12:41 Challenges in Singapore and in the world 13:19 Increase healthspan by slowing aging 14:37 Create a pipeline for healthy longevity 16:54 Potential in squaring the longevity curve 18:48 Validation of longevity interventions 21:00 Different biological clock 23:52 Connect the longevity pieces together 25:00 Hallmarks of aging 26:11 Seven pillars of aging are connected 27:58 Aging the biggest risk factor for age-related diseases 30:51 Combining longevity interventions 33:14 Risk of too much mTOR inhibition 36:14 Alpha-ketoglutarate (AKG) 39:38 Who benefits best in taking AKG 40:55 Brian's longevity stack 42:12 His experiences with Rapamycin 45:58 Cycling mTOR inhibition 48:20 Things to keep an eye on when taking Rapamycin 49:24 Start of a Rapamycin longevity trial 51:49 Rapalogs - Next generation mTOR inhibitors 53:02 Other ways to inhibit mTOR 54:44 Low vs high protein intake for longevity 57:26 Personalized longevity interventions 1:00:35 Personalized mTOR inhibition 1:01:43 Most promising longevity interventions 1:03:27 Brian's longevity protocol 1:06:28 How can longevity community speed up things 1:08:37 Contact information Links - The centre for Healthy Longevity at the National University of Singapore https://coe.nuhs.edu.sg/Centre-for-Healthy-Longevity/Pages/default.aspx - Healthy Longevity webinars on Youtube https://www.youtube.com/@NUSYLLSoM - Brian's LinkedIn https://www.linkedin.com/in/brian-kennedy-69777318 - Brian's Twitter account https://twitter.com/BKennedy_aging Rapamycin resources - Rapamycin Longevity Lab https://masteronething.com - Rapamycin.news https://www.rapamycin.news - Rapamycin Facebook group https://www.facebook.com/groups/rapamycin - Rapamycin Reddit group https://www.reddit.com/r/Rapamycin Connect with Krister on: Twitter: https://twitter.com/KristerKauppi Instagram: https://www.instagram.com/longevity.lifestyle.hacker Disclaimer: The podcast is for general information and educational purposes only and is not medical advice for you or others. The use of information and materials linked to the podcast is at the users own risk. Always consult your physician with anything you do regarding your health or medical condition.