Rapamycin's SURPRISING Effects on Aged IMMUNE SYSTEMS | 18 - RF #4

Subscribe to our channel: https://www.youtube.com/@optispan The R-Files episode 1: https://www.youtube.com/watch?v=czx_-DqnnrQ&t=1675s The R-Files episode 2: https://www.youtube.com/watch?v=EgIy0ghrDmo&t=140s The R-Files episode 3: https://www.youtube.com/watch?v=jLV5nOenD-g&feature=youtu.be The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and anti-proliferative effects. The drug has garnered attention for its potential anti-aging properties and has attracted research interest for its ability to extend lifespan and delay age-related diseases in various model organisms, including yeast and mice. In the fourth episode of the R-Files, Matt discusses research demonstrating that rapamycin rejuvenates the aged mouse immune system to respond to a flu vaccine as if it were in a youthful state. He also discusses papers suggesting that rapamycin may have similar effects on human immune systems. 0:00 Trailer 0:41 Introduction 1:25 A big year for rapamycin: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice 2:38 mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells 8:50 The immune challenge experiment 18:20 Unanswered questions 19:20 The lifespan experiment 25:26 Caveats 26:46 Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice 27:48 Translation to humans 28:27 TORC1 inhibition enhances immune function and reduces infections in the elderly 34:52 mTOR inhibition improves immune function in the elderly 38:44 Takeaways Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!