New Discovery: This Molecule Could Beat Rapamycin in Longevity

Subscribe to our channel: https://www.youtube.com/@optispan Get Our Newsletter (It's Free): https://www.optispan.life/ Dive into the future of longevity research with Dr. Ben Blue, CEO of Ora Biomedical. We explore how Ora's high-throughput "Wormbot" platform is conducting the world's largest unbiased search for longevity interventions, moving beyond the narrow focus on established pathways like mTOR. In this episode, we discuss: • The ambitious Million Molecule Challenge and why it could revolutionize the field. • Surprising discoveries already made, including molecules that outperform rapamycin. • Ora's strategic pivot to radiation resistance, with applications for astronauts, pilots, and human health. • How their data-driven approach is uncovering interventions for resilience against toxins and other stresses. • The journey from worm models to potential clinical trials and what's next for the company. Learn how Ora is scaling drug discovery to tackle aging and age-related diseases. https://orabiomedical.com/ https://x.com/OraBiomedical https://www.linkedin.com/company/ora-biomedical-inc/ This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here: https://onebillionmedia.com/ *Timestamps* 00:00 – Intro 01:13 – Welcome & Disclosure 02:40 – Ora Biomedical & the Longevity Mission 04:04 – How the Wormbot Was Born 06:43 – Matt's Perspective on the Wormbot 09:22 – Automating Lifespan Experiments at Scale 12:29 – The Million Molecule Challenge 15:03 – Success Stories from the Challenge 16:10 – A Better mTOR Inhibitor Than Rapamycin 19:05 – Ora's Molecule Beats Rapamycin 20:08 – 60% Lifespan Extension Discovery 24:03 – Ivermectin & Surprising Findings 24:55 – From Longevity to Anti-Parasite Drugs 31:09 – Hot Take: Discovery vs. Mechanism 35:22 – The Million Molecule Challenge Database 40:45 – Radiation Resistance: A New Focus 44:57 – Space Travel & Longevity Medicine 49:18 – Testing Resilience to Toxins & Stress 56:54 – What Thousands of Tests Reveal About Aging Pathways 01:00:41 – False Positives vs. False Negatives in Screening 01:04:45 – Skin Health & Anti-Aging Potential 01:07:59 – What's Next for Ora Biomedical DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://x.com/Optispan_Inc Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispan_/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!