Cellular Senescence Explained | Why Cells Stop Dividing? Aging, p53, Telomeres & SASP- Biotechnology
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Why do our cells stop dividing—and how does that lead to aging? The answer lies in a powerful process called cellular senescence.
Cellular Senescence: The Science of Aging Cells & Cell Cycle Arrest
Why Do Cells Stop Dividing? Cellular Senescence Explained (p53, Telomeres, SASP)
Aging at Cellular Level | Senescence, DNA Damage & Cancer Prevention
What is cellular senescence and why do cells stop dividing? In this video, we explore the complete molecular mechanisms behind cellular aging, including the role of p53, telomere shortening, and the DNA damage response.
Cellular senescence is a critical biological process where cells permanently exit the cell cycle to prevent the spread of damage. We explain how cells detect stress, activate tumor suppressor pathways, and enter a state of irreversible arrest. You will also learn about Replicative Senescence, Oncogene-induced Senescence, and the impact of Senescence-Associated Secretory Phenotype on aging and disease.
This video is perfect for students of biotechnology, life sciences, and those preparing for competitive exams like CSIR NET, GATE, and NEET PG.
Topics Covered:
What is cellular senescence?
How cells decide to stop dividing
Role of telomeres in aging
p53, p21, and p16 pathways
DNA damage response mechanism
Senescence vs apoptosis
SASP and inflammation
Role in aging and diseases like Cancer and Alzheimer's disease
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Nature is Ultimate · 8 min · Source published: 2026-03-21
Added to Harbor: 10/22/2026
Original on YouTube ↗Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.