L-BAIBA + Exercise Improve Muscle & Bone Health in Middle-Aged Mice | Aging-US

Aging-US #published this #research paper on October 1, 2025, in Volume 17, Issue 10, entitled “L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice" by #researchers from the Department of Biomedical Sciences, School of Medicine, University of Missouri, Kansas, MO; Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri, Kansas, MO; Department of Anatomy, Cell Biology and Physiology, School of Medicine, Indiana University, Indianapolis, IN; University of Missouri-Kansas City, Department of Civil and Mechanical Engineering, Kansas, MO; Department of Orthopaedic Surgery, School of Medicine, Indiana University, Indianapolis, IN. @UMKCMedicine #aging #exercise #electrocardiogram #endurance #det #paperspotlight #openaccess #openscience #peerreviewed #journal #publishing #meded DOI - https://doi.org/10.18632/aging.206325 Corresponding author - Michael J. Wacker — wackerm@umkc.edu Abstract Contracting skeletal muscles secrete the metabolite L-β-aminoisobutyric acid (L-BAIBA), which when supplemented in the diet can mitigate disuse-induced musculoskeletal dysfunction. However, the effects of L-BAIBA supplementation alone and combined with exercise on cardiac and musculoskeletal properties are currently unknown. We hypothesized that exercise with L-BAIBA supplementation would promote greater cardiac and musculoskeletal benefits than exercise alone. To investigate this hypothesis, we subjected 12-month-old (as a model of middle-age) male C57BL6 mice to voluntary wheel running (VWR) with L-BAIBA (100mg/kg/day) (VWR+L-BAIBA), VWR alone, L-BAIBA alone, or none (CTRL) for three months. After the intervention, conscious electrocardiogram showed slightly prolonged QTc in VWR+L-BAIBA mice compared to CTRL (p less than 0.05). Soleus muscles from VWR+L-BAIBA, but not VWR, were larger, contracted more forcefully, and contained more slow-oxidative type I myofibers compared to CTRL (p less than 0.05). In EDL muscle, VWR but not VWR+L-BAIBA improved fatigue resistance and caffeine-induced recovery (p less than 0.05). In bone, VWR+L-BAIBA but not VWR showed lower bone marrow adiposity, higher trabecular thickness, and connectivity, smaller bone diameter and Moment of Inertia, but higher Modulus of Elasticity than CTRL (p less than 0.05), suggesting L-BAIBA delays aging-induced periosteal expansion due to better bone material qualities. These findings suggest a physiological interaction between exercise and L-BAIBA supplementation to improve soleus muscle and bone properties and reduce bone marrow adiposity. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206325 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, endurance exercise, dietary supplementation, musculoskeletal adaptation, electrocardiogram To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM