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Video library· Quinn Stillson MD

Top 5 Supplements to Add YEARS to Your Life (Lifespan Extension Supplements)

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💊 Want to live longer and slow down aging? These are the Top 5 Supplements for Lifespan Extension backed by cutting-edge longevity research. In this video, I break down the best anti-aging supplements that target the root causes of aging—not just symptoms. These compounds are known as geroprotective agents, meaning they act on the 12 Hallmarks of Aging to extend lifespan and healthspan. If you’ve already watched my Top 5 Foundational Supplements for Longevity & Performance videos, this is your next step. Whether you want to live longer, feel younger, or slow biological aging, these are the most powerful longevity supplements to add to your stack. As a medical doctor (MD) and certified strength and conditioning coach, I’ll guide you through: ✅ The science behind each supplement and how it works to slow aging ✅ The best form, brand, and dose based on clinical evidence ✅ The right timing for real anti-aging, mitochondrial, and cellular benefits 🚀 Top 5 Supplements to Live Longer & Slow Aging (2025 Update) 1️⃣ Taurine – Boosts mitochondrial function, reduces oxidative stress, and increases lifespan by up to 25% in mice. (Best for energy, heart health, and aging mitochondria.) 2️⃣ Spermidine – Activates autophagy (cellular cleanup), decreases 9 hallmarks of aging, and supports healthy longevity. (Best anti-aging supplement for cell renewal.) 3️⃣ Green Tea Extract (EGCG) – Improves metabolism, reduces inflammation, and enhances mitochondrial resilience. (Best natural supplement for lifespan extension and longevity.) 4️⃣ Astaxanthin – Ultra-potent antioxidant (6,000x stronger than Vitamin C) that supports brain, skin, and heart health while extending lifespan in male mice. (Top antioxidant for aging and oxidative stress.) 5️⃣ Glycine (+ NAC) – Mimics methionine restriction, boosts glutathione, and extends lifespan in NIH Interventions Testing Program studies. (Best amino acid supplement for longevity and healthy aging.) 🔥 Timestamps 00:00 The 2 Types of Longevity Supplements - Intro to the Hallmarks of Aging 01:04 Taurine and its Impact on the Hallmarks of Aging 02:25 Taurine’s Lifespan Extension Evidence in Animals 05:46 Does Taurine Decrease with Age? Longitudinal vs Cross-Sectional Data 08:07 Taurine’s Impressive Human Data - Antioxidant and Antiinflammatory 09:24 How to Take Taurine for Lifespan Extension - Form, Dose, Timing, Brand 12:39 Spermidine’s Role in Autophagy and Other Hallmarks of Aging 15:11 Spermidine’s Lifespan Extension Evidence in Animals 16:18 Spermidine’s Human Data - High Intake Associated with Longevity 17:44 How to Take Spermidine for Lifespan Extension - Form, Dose, Timing, Brand 23:02 Green Tea Extract Polyphenol’s Impact on Aging Hallmarks 25:15 Green Tea Extract’s Lifespan Data (ITP Insights) 26:49 Green Tea Extract’s Human Data - Decreasing Biological Age 27:41 How to Take Green Tea Extract for Lifespan Extension - Form, Dose, Timing, Brand 34:16 Astaxanthin - Antioxidant that Inhibits Root Causes of Aging 35:54 Astaxanthin’s Lifespan Extension Evidence 37:34 How to Take Astaxanthin for Lifespan Extension - Form, Dose, Timing, Brand 41:38 Glycine’s Anti-Aging Mechanisms (Methionine Restriction) 43:49 Glycine + NAC - Lifespan Extension Evidence 45:51 Glycine + NAC Human Data - Most Impressive for Lifespan Extension? 46:41 How to Take Glycine and NAC for Lifespan Extension - Form, Dose, Timing, Brand 📢 Drop your thoughts in the comments — which of these would make your Top 5 Lifespan Extension list? Are you already taking any of them? ▶️ Watch More on Astaxanthin Here: Top 5 Unheard-Of Supplements for Longevity and Performance https://www.youtube.com/watch?v=kawHAKwM-mk&t=197s 🔔 Subscribe for more science-backed videos on longevity, functional medicine, and performance optimization. ⚕️ Medical Disclaimer: This video is for educational purposes only and does not constitute medical advice or a doctor-patient relationship. Always consult your licensed healthcare provider before starting any new supplement or treatment. #Longevity #Supplements #LifespanExtension #AntiAging #Taurine #Spermidine #GreenTeaExtract #Astaxanthin #Glycine #FunctionalMedicine #HealthOptimization

Quinn Stillson MD · 53 min · Source published: 2025-10-17

Added to Harbor: 10/22/2026

Original on YouTube ↗

Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.

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