Top expert increases the reliability of biological age estimates #epigenetics #longevity #insurance
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Renowned epigeneticist Raghav Sehgal discusses his pre-published study that discovers a new approach for reducing noise and improving the reliability of biological age estimates. This important advance allows us to use these estimates to track individual health and discover which unique health interventions work best for each of us.
Note on the research: When we recorded this conversation, the preprint we discussed covered both the reliability problem and its resolution. The authors have since split that work into two papers — the reliability findings are now peer-reviewed in Aging Cell (DOI: 10.1111/acel.70635), and the volatility-reduction work is being published separately and is not yet available.
Here's a link to the study itself:
https://onlinelibrary.wiley.com/doi/10.1111/acel.70635
Here's a link to the TranslAGE research platform with 179 harmonized DNA methlyation datasets used in the Study. https://www.translage.io/
Here's a link to another recent important study from Raghav and team that shares insights from 51 longitudinal studies of health interventions concluding that epigenetic clocks are responsive to multiple health-related interventions:
https://www.nature.com/articles/s41591-026-04562-9
Here's a link to Raghav's Podcast Channel "Decoding Longevity"
https://open.spotify.com/show/38rB6VfYGOItXZgMiCupKY
Raghav invites you to contact him through LinkedIn or Email:
https://www.linkedin.com/in/raghav-sehgal-yale/
raghav.sehgal@yale.edu
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Human Life Expectancy Channel · 62 min · Source published: 2026-01-21
Added to Harbor: 10/22/2026
Original on YouTube ↗Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.