Podcast description: centenarian genetics, aging drugs and biological age with Dr. Nir Barzilai

In this 130th episode of Sober Head Podcast, Dr. Esra Çavuşoğlu, PhD welcomes Dr. Nir Barzilai, MD. Dr. Nir Barzilai is Professor of Medicine and Genetics at Albert Einstein College of Medicine and Director of the Institute for Geroscience. He is one of the leading scientists in the fields of the biology of aging and the genetics of human longevity. His research focuses on protective genes that help delay aging and age-related diseases in centenarians, and he is also the driving force behind the TAME trial, which investigates the effects of metformin on aging. What if everything we think we know about longevity is wrong? Why do some people live beyond 100 despite smoking, being overweight, and never following a perfect health routine? In this episode of Sober Head podcast, I'm joined by Dr. Nir Barzilai, a pioneer in geroscience and longevity research, whose groundbreaking studies of centenarians have revealed how protective genetic mechanisms may delay age-related diseases and extend healthspan. We explore why exceptional longevity isn't just about diet, exercise, or supplements, and how growth hormone and IGF-1 may have dramatically different effects on aging depending on our biological age. Dr. Barzilai also explains the potential of metformin, GLP-1 drugs, SGLT2 inhibitors, and other gerotherapeutics to target the biology of aging rather than individual diseases. We discuss the science behind MOTS-c and Humanin peptides, the risks of unregulated peptide injections, the truth about longevity supplements, and what the evidence actually says about hyperbaric oxygen therapy, stem cells, and biological age testing. Can we slow biological aging, delay chronic disease, and remain healthy well into our 90s and beyond? The ultimate goal of longevity science may not be to live forever, but to compress illness into the shortest possible period at the end of life. Join us for a fascinating discussion about the future of aging, preventive medicine, and the science of living longer and healthier. #EsraÇavuşoğlu #AyıkKafa #ElevatingLifeEvolvingHealth #Longevilab #NirBarziali Dr. Nir Barzilai, MD Website: https://einsteinmed.edu/faculty/484/nir-barzilai Special thanks to T.C. Istanbul Gedik University https://www.gedik.edu.tr/en/ 00:00-05:06 Introduction to Dr. Nir Barzilai. 05:06-10:02 Why Centenarians Stay Healthy Longer 10:02-13:54 Longevity Genes: Living Unhealthily and Still Living Beyond 100! 13:54-18:03 Growth Hormone and IGF-1: Can More Be Harmful? 18:03-20:32 Why Hormones Affect Aging Differently After 50 20:32-22:59 Biological Age and Preventing Age-Related Disease 22:59-29:21 Longevity Supplements, Vitamin D and Clinical Evidence 29:21-33:39 Metformin, GLP-1 and Drugs That Target Aging 33:39-40:23 MOTS-c and Humanin: Peptide Benefits and Risks 40:23-45:00 Longevity Clinics, Hyperbaric Oxygen and Rapamycin 45:00-50:45 The Limits of Human Lifespan: Can We Reach 120? 50:45-55:00 Dr. Barzilai's Longevity Routine and Intermittent Fasting 55:00-58:00 Can Biological Age Tests Really Measure Aging? 58:00-59:28 When Should We Start Targeting Biological Aging? 59:28-1:02:01 Why is Metformin So Important? 1:02:01-1:02:38 Wrap up. *About Ayık Kafa* Dr. Esra Çavuşoğlu, PhD, took her studies, starting from her personal treatment experiences and continuing with her clinical psychology education, to the next level by completing her PhD focused on Addiction. Dr. Esra in Ayık Kafa podcast discusses the world’s latest technologies, protocols, products and research in the fields of Biohacking and Longevity, while sharing first-hand information and experiences about the Disease of Addiction, as well as her latest academic studies. *About Dr. Esra Çavuşoğlu, PhD* Longevilab’s founder, Dr. Esra, is a United States and internationally trained clinical psychologist and a certified addiction therapist in New York. She served as International Development Advisor on the Yale University Faculty of Medicine Clinical Advisory Board. She is the founder and supervisor of Gaziantep Oya Bahadır Yüksel Rehabilitation Center, Dr. Esra is the designer and implementer of the Turkey Rehabilitation Model. Dr. Esra founded the Contemporary Addiction Studies Association (ÇABAÇAD) in order to combat Turkey’s growing addiction problem. DisclaimerThe information and statements on our YouTube Channel Sober-Head are not intended to guide individuals towards medical diagnosis and treatment.Please consult with your doctor for medical diagnostic and treatment procedures.The content is shared for informational purposes only, derived from scientific studies prepared by EMC Medya Yayıncılık Ticaret Ltd. Şti.’s researchers, consultants, and authors/scientists, as well as compilations from publicly available public.