Inflammaging in the Fly: How Innate Immunity Shapes Lifespan

Disclaimer and context This podcast is based on a document created using Gemini Deep Research, and then the video podcast using Google Notebook LM. Gemini provided the references listed below as the basis for generating the source document, including the filtered papers selected after checking for duplication and source validity. Please note that this is an experimental exercise designed to explore how AI-assisted tools can help us learn about topics outside our immediate area of expertise in a simplified, accessible, and resource-efficient way. This content is not intended to be an academic document or a definitive review, but rather an exploration of how emerging technologies can support scientific learning, synthesis, and communication. If you identify inaccuracies, omissions, or points that require clarification, please feel free to leave a comment. Constructive criticism is very welcome, provided it is expressed in a professional and respectful tone. Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology The interplay between immunity and aging in Drosophila The Impact of Age on Response to Infection in Drosophila Developmental regulation of progenitor aging shapes long-term intestinal homeostasis in Drosophila Shared Transcriptomic Signatures of Inflammaging Among Diverse Strains of Drosophila melanogaster Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence The Drosophila JAK-STAT pathway in blood cell formation and immunity Layers of immunity: Deconstructing the Drosophila effector response Innate humoral immune defences in mammals and insects: The same, with differences? NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster Ptth regulates lifespan through innate immunity pathway in Drosophila Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system JAK/STAT Pathway Signalling in Drosophila melanogaster Microbiome contribution to Indy longevity in Drosophila Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging The role of Drosophila microbiota in gut homeostasis and immunity The Role of Microbiota in Drosophila melanogaster Aging Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction Sexual Dimorphisms in Innate Immunity and Responses to Infection in Drosophila melanogaster Sex-specific differences in the regulation and function of cellular immunity in Drosophila Sex and age specific reduction in stress resistance and mitochondrial DNA copy number in Drosophila melanogaster Markers and mechanisms of death in Drosophila Sex-Specific Gene Expression and Life Span Regulation Early life sleep is associated with longevity in Drosophila Glucose modulates Drosophila longevity and immunity independent of the microbiota Testing evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies (Drosophila melanogaster) Nutritional Programming of the Lifespan of Male Drosophila by Activating FOXO on Larval Low-Nutrient Diet Drosophila Undigested Metabolite Profiling reveals age related loss of intestinal amino acid transport regulates longevity Genotype-by-Environment Interactions and Adaptation to Local Temperature Affect Immunity and Fecundity in Drosophila melanogaster The effects of temperature on host–pathogen interactions in D. melanogaster: Who benefits? Diet impacts the effects of thermal stress on infection outcomes Applications and challenges of Drosophila melanogaster as a laboratory model in human cancer research: a narrative review Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues Keywords: Transformer, Toll, Spätzle, Smurf, Sirtuin, Relish, Prothoracicotropic, Oenocytes, Nubbin, Nepl15, Nemuri, Microbiome, Lifespan, Janus, Inflammaging, Indy, Immunosenescence, Hemocytes, Gnmt, Dysbiosis, Duox, Drosophila, Domeless, Caudal, Autophagy.