Matt Kaeberlein on Rapamycin Longevity Series | Lessons learned from 2 decades of Rapamycin research

Professor Matt Kaeberlein from the University of Washington is one of the world's leading researchers in the Rapamycin field. He has done Rapamycin research on multiple species for two decades. Everything from yeasts, worms, mice and now also dogs and humans. Matt has made a big contribution to the longevity field and in this podcast he will share the knowledge he has acquired in the field. 00:00 Intro 01:30 How Matt's Rapamycin research started 05:40 First study which showed Rapamycin extends lifespan 07:14 mTOR genetic mutations in humans 09:26 mTOR genetic variants in long-lived humans 10:25 Laron syndrome and effects on mTOR 12:28 Why does mTOR inhibition works so well 13:02 mTOR have two parts mTORC1 and mTORC2 15:18 Rapamycin extends lifespan in multiple species 17:54 Rapamycin effects on the hallmarks of aging 22:52 First Rapamycin ITP study in mice 23:24 ITP study lead to a longevity paradigm shift 33:21 Rapamycin aging effects on mice 37:48 What is Rapamycin 38:30 Rapamycin is a immunomodulator 41:36 Rapamycin improves immune function 50:24 How aging impacts the immune system 55:17 The dog aging project 1:01:08 Effects on time restricted eating on dogs 1:10:19 Rapamycin trial on dogs 1:14:45 Rapamycin trial dose regime in dogs 1:16:57 Rapamycin safety trial results in dogs 1:19:37 Prediction of best Rapamycin effect in humans 1:22:56 Rapamycin human survey study 1:31:58 Longevity interventions and side effects 1:37:35 Biomarkers and measurements 1:41:59 Matt's Rapamycin usage 1:44:14 Optimal dose regime of Rapamycin 1:44:39 Matt's beneficial effects with Rapamycin 1:46:12 Side effects Matt has experienced 1:47:17 Matt's risk and benefit calculation 1:51:22 Matt's view on self-experimentation 1:55:43 The three most promising longevity interventions 1:57:57 Other longevity interventions like NAD, Metformin, Spermidine and AKG 2:02:27 Combination of longevity interventions 2:10:14 Do high doses cross the blood-brain barrier? 2:12:39 Weak points regarding Rapamycin 2:16:05 Rapamycin research is underfunded 2:17:59 Can Rapamycin result in disease or worsen any disease? 2:21:14 Rapamycin effect on appearance and skin health 2:25:10 Matt's future plans Links - The Dog Aging Project (possible to still apply) https://dogagingproject.org - Ora Biomedical https://orabiomedical.com - Optispan https://optispan.life - Matt's twitter https://twitter.com/mkaeberlein - Photo credit to Tammi Kaeberlein from Wander Healthy https://twitter.com/KaeberleinTammi Rapamycin resources - Rapamycin Longevity Lab https://masteronething.com - Rapamycin.news https://www.rapamycin.news - Rapamycin Facebook group https://www.facebook.com/groups/rapamycin - Rapamycin Reddit group https://www.reddit.com/r/Rapamycin Connect with Krister on: Twitter: https://twitter.com/KristerKauppi Instagram: https://www.instagram.com/longevity.lifestyle.hacker Disclaimer: The podcast is for general information and educational purposes only and is not medical advice for you or others. The use of information and materials linked to the podcast is at the users own risk. Always consult your physician with anything you do regarding your health or medical condition.