NAD+ Levels: What Human Studies Show About Aging, Exercise & NMN

NAD+ levels are often presented as a simple aging story. Human studies show a more complicated picture. In this video, we look at what NAD+ levels actually mean, why blood and tissue measurements can differ, what human research shows about aging and exercise, and what we know so far about raising NAD+ with NMN and NR.* We also cover why a blood NAD+ result is not the same thing as a whole-body health score. Read the full CELLSHE article: NAD+ Levels by Age https://cellshe.com/blogs/journal/nad-levels-by-age?utm_source=youtube&utm_medium=video&utm_campaign=nad_levels_explained Explore CELLSHE NMN 500 https://cellshe.com/products/nmn-500?utm_source=youtube&utm_medium=video&utm_campaign=nad_levels_explained CHAPTERS 00:00 NAD+ levels: the simple story vs human evidence 00:46 What does an NAD+ level mean? 01:13 Does NAD+ decline with age? 01:51 Exercise, food and everyday health 02:52 NMN, NR and raising NAD+ 03:41 Should you test your NAD+? 04:18 What should we take from this? KEY HUMAN STUDIES USED IN THIS VIDEO Trętowicz MM, et al. Human whole-blood NAD+ levels do not vary with age or lifestyle interventions. Nature Metabolism. 2026. https://doi.org/10.1038/s42255-026-01537-5 Janssens GE, et al. Healthy aging and muscle function are positively associated with NAD+ abundance in humans. Nature Aging. 2022. https://doi.org/10.1038/s43587-022-00174-3 de Guia RM, et al. Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle. Physiological Reports. 2019. https://doi.org/10.14814/phy2.14139 Yi L, et al. The efficacy and safety of β-nicotinamide mononucleotide supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled trial. GeroScience. 2023. https://doi.org/10.1007/s11357-022-00705-1 Morifuji M, et al. Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults. GeroScience. 2024. https://doi.org/10.1007/s11357-024-01204-1 Christen S, et al. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans. Nature Metabolism. 2026. https://doi.org/10.1038/s42255-025-01421-8 CHAPTERS 00:00 NAD+ levels: the simple story vs human evidence 00:38 What does an NAD+ level mean? 01:05 Does NAD+ decline with age? 01:34 Exercise, food and everyday health 02:22 NMN, NR and raising NAD+ 03:01 Should you test your NAD+? 03:31 What should we take from this? Disclosure: CELLSHE sells NMN supplements. We link the human evidence behind the claims discussed here so you can review the research directly. Explore the human evidence behind CELLSHE https://cellshe.com/pages/science?utm_source=youtube&utm_medium=video&utm_campaign=nad_levels_explained This video is for general education and is not medical advice. Dietary supplements are not intended to diagnose, treat, cure or prevent disease. #NAD #NMN #HealthyAging "This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.