Measuring Time In Molecules: The Science Of Biological Age

Measuring Time In Molecules With Dr. Laurena Law ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ In this video, I invite Dr Chandni Kumar, a friend and repeat guest to discuss DNA methylation clocks and proteomic clocks which are being developed to measure biological age as well as their development to be used as biomarkers to assess longevity interventions. You can subscribe to her here: @DDHS_Podcast References provided by Dr Kumar: [1] Gillespie, C.A., Chowdhury, A., Quinn, K.A. et al. Fundamentals of DNA methylation in development. Pediatr Res (2024). https://doi.org/10.1038/s41390-024-03674-7 [2] Moore, L., Le, T. & Fan, G. DNA Methylation and Its Basic unction. Neuropsychopharmacol 38, 23–38 (2013). https://doi.org/10.1038/npp.2012.112 [3] Lakshminarasimhan, Ranjani, and Gangning Liang. “The Role of DNA Methylation in Cancer.” Advances in experimental medicine and biology vol. 945 (2016): 151-172. doi:10.1007/978-3-319-43624-1_7 [4] Tsai Y-H, Mitra P, Taniar D and Pai T-W (2025) DNA methylation biomarker analysis from low-survival-rate cancers based on genetic functional approaches. Front. Bioinform. 5:1523524. doi: 10.3389/fbinf.2025.1523524 [5] Nadiger, N., Veed, J.K., Chinya Nataraj, P. et al. DNA methylation and type 2 diabetes: a systematic review. Clin Epigenet 16, 67 (2024). https://doi.org/10.1186/s13148-024-01670-6 [6] Kwon, HJ., Shin, S.H., Kim, H.H. et al. Advances in methylation analysis of liquid biopsy in early cancer detection of colorectal and lung cancer. Sci Rep 13, 13502 (2023). https://doi.org/10.1038/s41598-023-40611-w [7] Gibson, Jude et al. “A meta-analysis of genome-wide association studies of epigenetic age acceleration.” PLoS genetics vol. 15,11 e1008104. 18 Nov. 2019, doi:10.1371/journal.pgen.1008104 [8] Shireby, Gemma L et al. “Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.” Brain : a journal of neurology vol. 143,12 (2020): 3763-3775. doi:10.1093/brain/awaa334 [9] Fraszczyk, Eliza et al. “DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes.” GeroScience vol. 44,6 (2022): 2671-2684. doi:10.1007/s11357-022-00626-z [10] El Khoury, Louis Y et al. “Systematic underestimation of the epigenetic clock and age acceleration in older subjects.” Genome biology vol. 20,1 283. 17 Dec. 2019, doi:10.1186/s13059-019-1810-4 [11] Argentieri, M.A., Xiao, S., Bennett, D. et al. Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med 30, 2450–2460 (2024). https://doi.org/10.1038/s41591-024-03164-7 [12] Proteomic aging signatures predict disease risk and mortality across diverse populations. Nat Med 30, 2415–2416 (2024). https://doi.org/10.1038/s41591-024-03170-9 [13] Kuo, Chia-Ling et al. “Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults.” Aging cell vol. 23,8 (2024): e14195. doi:10.1111/acel.14195 [14] Chen, Qingwen et al. “OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records.” bioRxiv : the preprint server for biology 2023.10.16.562114. 24 Oct. 2023, doi:10.1101/2023.10.16.562114. Preprint. [15] Lehallier, B., Gate, D., Schaum, N. et al. Undulating changes in human plasma proteome profiles across the lifespan. Nat Med 25, 1843–1850 (2019). https://doi.org/10.1038/s41591-019-0673-2 Video Keywords: Measuring time with molecules, molecular clock research breakthroughs, atomic timekeeping with molecules, quantum time measurement techniques, ultrafast molecular motion tracking, molecular dynamics time resolution, femtosecond spectroscopy in chemistry, chemical reaction time scale, time measurement in physics, molecular vibration time tracking, picosecond time scale experiments, molecules as time indicators, nanosecond molecular decay measurement, laser pulses measure molecules, time-resolved molecular imaging, real-time chemical process analysis, atomic and molecular clocks, timekeeping using molecular oscillations, ultrafast chemical reaction tracking, subatomic particle time behavior, quantum clocks using molecules, measuring femtosecond molecular changes, real-time molecular motion study, time perception in molecules, spectroscopy to track time, chemical kinetics and timing, measuring time molecular precision, molecular frequency time scales, tracking time at nanoscale, timekeeping breakthroughs in chemistry. #measuring #measuringcups #measuringtools #measuringtape #measuringtool #measuringinstruments #molecules #molecule #moleculeman #menopausehealth #doctor #healthylifestyle #menopause #healthyfood #hormonetherapy #ménopause #womenshealth