Matt Kaeberlein - Aging, mTOR, Epigenetic Clocks, and more! @optispan

What if aging isn’t just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/ - 🎁 Special offers from our podcast guests: 🧬 Telo-Vital (Dr. Bill Andrews) – 55% Off: Get your first bottle for $49 with free shipping to US, UK, Canada, Mexico, Australia, New Zealand & 20+ European countries. Link: longevityroadmap.thegoodinside.com/special-offer-telo-vital-lp 🌱 Stemregen (Dr. Christian Drapeau) – 15% Off: Use code LONGEVITYROADMAP (one-time purchase, new customers only, one use per customer, cannot combine discounts). Link: stemregen.co/collections/all 🐟 Fatty15 (Dr. Stephanie Venn-Watson) – 15% Off: Save on your first order. Link: fatty15.com/LONGEVITYROADMAP 💧 OneSkin (Dr. Carolina Reis Oliveira) – 15% Off: Use code BUCK at checkout if the discount is not automatically applied. Link: oneskin.co/BUCK 🧠 Nuchido (Dr. Nichola Conlon) – 20% Off: Use code SAPIO20 at checkout. Link: nuchido.com ⚡ AX3 (David M. Watumull) – 20% Off: Use code ROADMAP20 if the discount is not automatically applied. Link: glnk.io/5w7jn/longevity-roadmap