Dr. Kara Fitzgerald: Biological Age, Epigenetic Clocks, and the Future of Aging Reversal

Most people think aging is fixed, but new science shows we can measure it, influence it, and in some cases even reverse it. From epigenetic clocks to nutrition-driven gene expression, aging is no longer just about time, it is about how your biology responds to your environment and choices. In this episode of Extend, I sit down with Dr. Kara Fitzgerald, functional medicine leader, researcher, and author, to unpack how diet, lifestyle, and emerging longevity science are reshaping how we understand aging. We explore biological vs chronological age, how epigenetic clocks work, and why aging may be driven by both environmental exposures and deeper programmed mechanisms. We break down how polyphenols, urolithin A, and nutrient-dense diets can influence gene expression, how exposomic and programmed aging interact, and what Yamanaka factors reveal about the future of age reversal. We also explore early research on Yamanaka mimetics and how precision data and targeted interventions may help extend both healthspan and peak performance. ✅ We Also Discuss: ➡️ Biological age vs chronological age ➡️ Epigenetic clocks and how aging is measured ➡️ Exposomic aging and lifestyle impact ➡️ Programmed aging and lifespan limits ➡️ Polyphenols and gene expression ➡️ Urolithin A and mitochondrial function ➡️ Organ-specific aging and biomarker tracking ➡️ Yamanaka factors and cellular reprogramming ➡️ Yamanaka mimetics and future interventions ➡️ Caloric restriction and aging pathways ➡️ Nutrition strategies for biological age reversal Subscribe for science driven conversations on longevity, performance, and the strategies that help you optimize your healthspan. Thank You to Our Sponsors: IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH. Momentous: Head to http://livemomentous.com/fiber and use code DRSHAH for up to 35% off your first order. Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/ Learn more about Dr. Kara Fitzgerald: Website: https://www.drkarafitzgerald.com/ Podcast: https://www.drkarafitzgerald.com/fxmed-podcast/ Webinars: https://www.drkarafitzgerald.com/webinars/ Instagram: https://www.instagram.com/drkarafitzgerald Facebook: https://www.facebook.com/DrKaraFitzgerald YouTube: https://www.youtube.com/channel/UC7jYgG7WMnqPeC4uwslqdfQ X: https://x.com/kfitzgeraldnd Pubmed: https://pubmed.ncbi.nlm.nih.gov/33844651/ Pubmed: https://pubmed.ncbi.nlm.nih.gov/36947707/ Pubmed: https://pubmed.ncbi.nlm.nih.gov/40266024/ Hashtags: #BiologicalAging #Epigenetics #LongevityScience #Healthspan #PeakSpan #Biohacking #FunctionalMedicine #PrecisionHealth #MitochondrialHealth #NutritionScience #Polyphenols #UrolithinA #YamanakaFactors #AgeReversal #Biomarkers #DrDarshanShah #ExtendPodcast