Stem Cells, Aging Hallmarks & Rapamycin | 49 - Kevin White

Subscribe to our channel: https://www.youtube.com/@optispan Check out Prime Health Associates: https://www.primehealthassociates.com/ Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the gerosciencefield. One of these was Kevin White, physician at longevity-focused clinic Prime Health Associates in Oklahoma City, Oklahoma. Kevin spent two decades in emergency medicine before obtaining fellowship training in integrative and functional medicine, nutrition, and age management. He complete residency training in emergency medicine and trauma at Washington University in St. Louis, and received his M.D. from the University of Oklahoma College of Medicine. Matt describes him as "one of the few longevity docs who actually comes to the science meetings to learn more about the science of aging." Ultimately, the geroscience field is nothing without the medical professionals who bring new discoveries to bedside. So we really enjoyed sitting down with Kevin and hearing his thoughts on interventions such as stem cell therapy as well as his questions about the geroscience field, which prompted a wide-ranging discussion of rapamycin, the hallmarks of aging, body composition, and more. 0:00 Introduction 3:30 How does rapamycin actually work? What is mTOR? 7:51 The two flavors of mTOR 9:25 What we know about rapamycin's effects on model organisms and humans 16:52 Rapamycin's effects on klotho levels 18:48 Can Matt name the 12 hallmarks of aging? 21:28 Matt's views on stem cell exhaustion/stem cell therapy 26:19 Kevin's views on stem cell therapy 28:13 Environmental factors that might reduce stem cell exhaustion 30:40 Geroscience research that excites Matt + rapamycin research in primates 32:50 Matt's current body composition stats and goals 37:17 Wrapping up Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!