Endocrine Mimicry: How Microbes Control Your Hormones - MicroBiome 9

Get the Free Secret Chapter and learn to use the Parallel Productivity Prompts and learn how to get more done without sacrificing your relationships.. 👉 https://shr.pn/pMq9 -------------------------------------------------------------------------------- Video Description Welcome to Episode 9! In this chapter, we explore the fascinating world of Endocrine Mimicry & The Therapeutic Window. We visualize Short-Chain Fatty Acids (SCFAs) as "master keys" that perfectly fit into golden locks along your intestinal lining, opening the floodgates for powerful hormones to enter your system . In this video, you will learn: • Nature's Weight-Loss Hormones: How microbial metabolites act as powerful endocrine mimics. Watch as butyrate stimulates the secretion of GLP-1 and PYY, serving as a natural secretagogue for the exact same biological pathways targeted by modern blockbuster weight-loss pharmaceuticals . • The Propionate Paradox: Discover the strict "therapeutic window" of the SCFA propionate. While physiological levels are essential for protecting your cerebrovascular endothelial cells (your blood-brain barrier), we explain how excessive amounts have been linked to neurotoxicity in models of propionate-induced autism . • The Western Diet's Toll: We dive into data from the SOURCE Cohort, demonstrating how a Western dietary pattern directly drives intestinal barrier failure . See how urbanization correlates with a dangerous increase in inflammatory Fusobacteriaceae and a critical loss of protective Bifidobacterium longum . If you found this deep dive into endocrine mimicry eye-opening, make sure to like, subscribe, and hit the bell icon so you don't miss our series finale, Episode 10, where we will cover ocular, respiratory, and iatrogenic microbiome risks! -------------------------------------------------------------------------------- Disclaimer Medical Disclaimer: The content in this video is strictly for educational and informational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition, diet, or supplementation. -------------------------------------------------------------------------------- References & Further Reading Want to dive deeper into the science of microbial metabolites, GLP-1, and the SOURCE Cohort discussed in this episode? Check out the studies below: Tolhurst, G., et al. (2012). "Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2." Diabetes, 61(2), 364–371 . Yadav, H., et al. (2013). "Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion." Journal of Biological Chemistry, 288(35), 25088–25097 . Hoyles, L., et al. (2018). "Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier." Microbiome, 6(1), 55 . Choi, J., et al. (2018). "Pathophysiological and neurobehavioral characteristics of a propionic acid-mediated autism-like rat model." PLoS ONE, 13(2), e0192925 . Braun, T., et al. (2024). "Diet-Omics in the Study of Urban and Rural Crohn Disease Evolution (SOURCE) Cohort." Nature Communications, 15, 3764 .