NR vs NMN vs NAM : Who Wins in Human NAD Trial?

New human study directly compares nicotinamide riboside (NR), NMN, and nicotinamide for raising NAD levels. Surprising results show the gut microbiome plays a key role in determining which supplements sustain higher baseline NAD over time. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg, NMN 1g https://prohealth.pxf.io/3exEAv ~~~~~~~~~~~~~~ A new randomized, placebo-controlled human study published in Nature Metabolism directly compared three popular NAD precursors: nicotinamide riboside (NR), NMN, and nicotinamide. After 14 days of supplementation, NR and NMN roughly doubled baseline NAD levels in whole blood, while nicotinamide showed no significant effect despite producing large acute spikes. The study reveals that NR and NMN are processed first by gut bacteria, converting them to nicotinic acid before contributing to systemic NAD production through the Preiss-Handler pathway. This explains why they don't spike immediately in blood but sustain higher baseline levels over time. The findings challenge the assumption that these compounds are interchangeable and highlight the critical role of the gut microbiome in NAD metabolism. This video breaks down the study design, results, and what they mean for choosing NAD supplements. 📚 Chapters 0:00 - Introduction: Which NAD Booster Works Best? 1:16 - Study Design: Comparing NR, NMN, and Nicotinamide 2:37 - Chronic Effects: Which Supplements Raised Baseline NAD? 4:41 - Acute Effects: The Paradox of Blood Spikes vs. Sustained Levels 5:53 - The Gut Microbiome's Role in NAD Metabolism 9:08 - Summary: Two Different Pathways to Raising NAD 🌐Links in this video The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans https://www.nature.com/articles/s42255-025-01421-8 *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to legal@wevideo.com. ********************************************** #NMN #NR #clinicaltrial