Adam Gries - Longevity & the Fight to Defy Aging

Adam Gries is a serial entrepreneur, software engineer, and prominent advocate in the longevity and vitalism movement. He has founded and sold four companies, including OKpanda and Material World, with his products reaching over 80 million users. Gries is currently dedicated to the mission of ending aging and extending human healthspan. 0:00 Intro 0:53 Talk: Longevity and the Fight to Defy Aging 1:46 Who & how are we involved in longevity? (Adam Gries, Vitalism Foundation) 2:50 80% of us are on track to decline & die of aging - it's not a choice (for now) - Aging is the primary cause of death) 3:05 Aging is the #1 risk factor 3:57 Healthy aging is an oxymoron - we lose most of our capacity with aging 4:54 Humanity is fighting aging as hard as possible 6:33 Aging has economies on track to insolvency - we spend our money all wrong 7:41 Penny wise, pound foolish - Despite clear evidence aging is modifiable 9:23 As of 2025, 0 intervensions approved for aging in humans - so why is longevity suddenly so vogue? 9:51 Scientific progress, alongside an explosion of data, diagnostics and AI 10:36 Agenda: i) Do this now, ii) Existing innovation is great; but too little, iii) How we can still win 10:54 The Health Pyramid, know your data - supplements & biomarkers 12:50 Get a wearable, and track sleep 13:26 Get a DEXA scan, use CMG to understand blood glucose response 15:05 Check heart disease status, have a basic skincare routine 16:00 Ensure good air quality, do recommended tests for your age 16:47 Vo2 Max, full body MRI 19:50 Warnings 21:16 The health pyramid - make a plan - services that can help (including AI) 22:10 Best intervensions if already healthy? Excercise & nutrition - Warning: stemcells, peptides, exosomes 23:32 The health pyramid - do it - efforts can be delegated (but options are limited) 25:06 A couple of near-term concerns - presbyopia (treatment in development), ovarian cryopreservation 27:16 Hallmarks of aging and the statistical fact that risk rises with aging 28:54 What can existing interventions do? (how much life/healthspan can we achieve?) 32:22 How to guard against being unjustifiably ahead of the evidence 36:14 Longevity is an inevitable, massive growth opportunity - Longevity Biotech history 38:08 Longevity Biotech at a glance - Aging drug clinical trials - major funding is pouring in 39:32 GLP1 antagonists may be the first Longevity Therapy, PCSK9 inhibitor gene therapies 40:57 Longevity biotech Investor Landscape 46:21 Xenotransplantation, Xeno human organ growth, Embryonic Gene editing, Brainless clones (whole body transplants) 50:59 Section for Q&A 52:33 Regulation that doesn't strangle innovation 55:29 The need for quality data - AI labs working on aging 57:13 How we can still win? Attention upsteam of policy, money, and brains - money is never enough, 58:21 How to get a lot more attention 59:33 Comparing strategies to get more attention - building influence networks 1:04:17 Case study: tech libertarian influence network 1:06:48 Vitalism - longevity influence network 1:08:43 Vitalism grand strategy - we are in phase 2 - Vitalist Bay conference 1:11:15 What are you most excited about? Muscle preserving intervensions, some types of stem cell therapies, weight loss, gene therapies 1:14:47 Aging may require long trial phases 1:20:06 Non-partisan cross-party alignment Many thanks for tuning in! Please support SciFuture by subscribing and sharing! Buy me a coffee? https://buymeacoffee.com/tech101z Have any ideas about people to interview? Want to be notified about future events? Any comments about the STF series? Please fill out this form: https://docs.google.com/forms/d/1mr9PIfq2ZYlQsXRIn5BcLH2onbiSI7g79mOH_AFCdIk/ Kind regards, Adam Ford - Science, Technology & the Future - #SciFuture - http://scifuture.org