Will This Weight Loss Peptide Extend Lifespan? | Dr Mikhail Kolonin

Dr. Mikhail Kolonin discusses the impact of GLP-1 agonists on human lifespan, the risks of muscle wasting in older adults, and why these "weight loss molecules" are not a substitute for a healthy lifestyle. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ In this final segment, Dr. Mikhail Kolonin explores the intersection of GLP-1 agonists and longevity science. While these molecules effectively reduce all-cause mortality by mitigating obesity-related diseases, Dr. Kolonin reveals the surprising lack of direct lifespan data in both humans and animal models. We discuss the biological mechanisms of adipose tissue browning, the role of IL-6 signaling, and the specific risks of sarcopenia for patients over 60. Dr. Kolonin also addresses the recent failure of GLP-1s in Alzheimer’s clinical trials and why a "silver bullet" approach to pharmacology can lead to metabolic resistance and muscle loss. This deep dive provides a critical look at whether these molecules truly extend healthspan or simply normalize physiology, offering essential advice for those using these treatments to maintain muscle mass and metabolic health as they age. 📚 Chapters 0:00 Do GLP-1s Actually Extend Lifespan? 1:58 The Impact on All-Cause Mortality 3:53 Why Lifestyle Still Beats Pharmacology 6:05 Semaglutide vs. Dulaglutide: Does it Matter? 8:55 Can Exercise Prevent Muscle Wasting? 11:22 The "Silver Bullet" Myth & Alzheimer's Trials 14:11 Risks for the 60+ Demographic 🌐Links in this video Dr Kolonin's page https://gsbs.uth.edu/directory/profile?id=b816c8de-c9b0-40f0-873c-42fa69db82e9 #glp1 #Longevity #mitochondria