Translating Geroscience into Function — A Conversation with Steve Kritchevsky

What if the most important metric of aging isn’t how long we live — but how well we function? In Episode 23 of Decoding Longevity, Raghav Sehgal and Macsue Jacques are joined by Stephen Kritchevsky to unpack the biology of mobility, metabolism, and resilience. This episode explores: • Why walking speed predicts health, cognition, and survival • The difference between muscle mass vs. muscle quality • What decades of clinical trials reveal about aging trajectories • How brain and body aging are deeply interconnected • What it would take to actually measure a therapy that slows aging A grounded, clinical perspective on longevity — focused on independence, function, and real-world outcomes.