Silencing Nr4a3 Unlocks Regenerative Cardiac Programmes in Senescent Cells
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Creator description · original textText language: English
The link to the paper: https://www.science.org/doi/pdf/10.1126/sciadv.adz4847
Key-words: Actc1, Aged fibroblasts, ATAC-seq, Cardiac fibroblasts (CFs), Cellular senescence, Chromatin accessibility, Cxcl14, Direct cardiac reprogramming, Epigenetic barriers, Flow cytometry (FACS), Gata4, H3K27ac, Induced cardiomyocytes (iCMs), Mef2c, Myocardial Infarction (MI), Myocardin (Myocd), Nr4a3, Postn, RNA-seq, RNA velocity, SA-β-gal staining, Sarcomere, SASP, Senolytic treatment, Tbx5
The Sanz Science Experience · 13 min · Source published: 2025-11-21
Added to Harbor: 10/29/2026
Original on YouTube ↗Automatically categorized source. Creator statements are not an independent evidence review or personal medical guidance.