Title: Rapamycin for Longevity – Latest Science & Practical Insights

In this video, I dive into the latest research on rapamycin for longevity, breaking down key findings from a 2024 Lancet Healthy Longevity article on its potential as an anti-aging therapy ( https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext ). We’ll discuss how rapamycin works, its effects on mTOR inhibition, and the most common dosing strategies used in longevity protocols. Additionally, I highlight key insights from Peter Attia’s podcast with leading experts David Sabatini & Matt Kaeberlein, where they explore rapamycin’s potential to extend lifespan, its risks, and what human trials are telling us so far ( https://peterattiamd.com/davidsabatini-mattkaeberlein/ ). Topics Covered: ✅ How Rapamycin Works for Longevity & Aging ✅ Latest Clinical Findings & Animal Study Insights ✅ Common Dosing Protocols for Longevity (6-10mg Weekly?) ✅ Risks, Side Effects & Who Should Consider It ✅ What Experts Like Peter Attia, David Sabatini, & Matt Kaeberlein Say ✅ Natural mTOR Inhibitors That Support Longevity Natural Substances That Inhibit mTOR: Several natural compounds have been shown to modulate or inhibit mTOR, potentially mimicking some of rapamycin's longevity effects: 🌱 Resveratrol – Found in grapes and red wine, known for its anti-inflammatory and longevity-promoting effects. 🥦 Sulforaphane – A potent compound in cruciferous vegetables like broccoli, linked to cellular protection and mTOR inhibition. 🫚 Curcumin – The active compound in turmeric, shown to modulate mTOR pathways and reduce inflammation. 🍵 EGCG (Epigallocatechin Gallate) – Found in green tea, supports autophagy and inhibits mTOR. 🌰 Quercetin – A flavonoid in onions and apples that helps reduce inflammation and modulate aging pathways. 🥑 Berberine – A plant alkaloid that mimics some effects of metformin and may influence mTOR signaling. 🍽 Fasting & Caloric Restriction – Naturally inhibits mTOR and promotes autophagy, enhancing cellular repair and longevity. 🔥 Ketogenic Diet & Low Protein Intake – Lowering dietary methionine and branched-chain amino acids (BCAAs) can downregulate mTOR activity. Is Rapamycin the next big breakthrough in longevity science? Let’s explore the data and practical applications! 🔔 Subscribe to my YouTube channel here: https://www.youtube.com/@DrMishaKogan #Rapamycin #Longevity #AntiAging #mTOR #PeterAttia #DavidSabatini #MattKaeberlein