AFTER 70: WHAT MAKES YOUR ARTERIES STIFF? DIET MAY NOT FIX IT

A clinical trial broke a specific chemical bond in stiffened human arteries and measurably improved arterial compliance — real proof that advanced glycation end-products (AGEs) cause vascular stiffening. But a separate study of over 2,200 people found no link between how many AGEs someone ate and their arterial stiffness. This episode explains the real cross-linking mechanism, the drug trial that proved it, and the more precise, current picture of where these molecules actually come from — your blood sugar, more than your dinner plate. 00:00 – A drug that reversed arterial stiffness, and a study that complicates the story 2:00 – What these molecules actually are, and where they come from 4:00 – Why these molecules stiffen your arteries 6:00 – The part most content on this topic leaves out 7:30 – The retention moment: where the chemistry actually runs 8:15 – Closing: what to actually watch DISCLAIMER This is for educational content only — not medical advice. #AdvancedGlycationEndProducts #ArterialStiffness #VascularAging #BloodSugar #CardiovascularHealth #RAGE #NutritionScience #longevity SOURCES USED Kass, D.A. et al. (2001). Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation, 104(13), 1464–1470. Linkens, A.M.A. et al. (2021). Habitual Intake of Dietary Advanced Glycation End Products Is Not Associated with Arterial Stiffness of the Aorta and Carotid Artery in Adults: The Maastricht Study. Journal of Nutrition, 151(8), 2274–2283. Randomized controlled trial (2022). Dietary Intake of Advanced Glycation End Products Did Not Affect Endothelial Function and Inflammation in Healthy Adults. Journal of Nutrition. Study in type 2 diabetes (2017). High intake of dietary advanced glycation end-products is associated with increased arterial stiffness and inflammation in subjects with type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases. Semba, R.D. et al. (2009). Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults. American Journal of Hypertension.