The Biggest Problems in Longevity Science

Subscribe to our channel: https://www.youtube.com/@mkaeberlein What does "longevity" really mean? Are biological age tests ready for clinical use? Is rapamycin still the most promising longevity drug? And where do GLP-1 medications fit into the future of healthy aging? In this fireside chat from the Longevity Investors Conference, I discuss some of the biggest questions facing longevity science today—and why separating rigorous evidence from hype is more important than ever. Full video here: https://www.youtube.com/watch?v=Q-P7ryjS_SY Topics include: What longevity really means—and why definitions matter Why I believe today's biological age tests are not ready for clinical decision-making What biomarkers are actually useful today The promise and limitations of rapamycin GLP-1 agonists and their potential effects beyond weight loss Why we need more data on combination longevity therapies What the Dog Aging Project is teaching us about healthy aging Why companion dogs may be the best bridge between laboratory discoveries and human longevity The importance of discovery science beyond the current "hallmarks of aging" How AI can accelerate aging research—but only if it's built on high-quality biological data The field of longevity is advancing rapidly, but meaningful progress requires careful science, healthy skepticism, and a willingness to challenge our own assumptions. My hope is that this conversation helps clarify where the evidence is strongest, where uncertainty remains, and where I believe the greatest opportunities lie. Chapters 00:00 What is longevity? 02:00 Healthspan vs. lifespan vs. "joyspan" 02:55 Why biological age tests don't measure aging 06:00 Should doctors use aging clocks? 09:10 The Dog Aging Project 13:00 Rapamycin: promise and uncertainty 14:20 GLP-1 drugs and combination therapies 15:20 Are the hallmarks of aging enough? 16:40 Why discovery science still matters If you enjoy evidence-based discussions on aging biology, healthspan, and longevity medicine, be sure to subscribe to Longevity Science for new interviews, deep dives, and commentary. #Longevity #HealthyAging #Rapamycin #GLP1 #BiologicalAge #AgingResearch #Healthspan #DogAgingProject #Geroscience #LongevityScience DISCLAIMER: The information provided on this channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find me: Instagram: https://www.instagram.com/mkaeberlein/ LinkedIn: https://www.linkedin.com/in/mkaeberlein/ Twitter: https://twitter.com/mkaeberlein Facebook: https://www.facebook.com/matt.kaeberlein/ --- Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!