Why You're Aging Faster Than You Should (And How to Stop It)

What if most anti-aging advice is noise — and the real answer is much simpler? In this episode, Dr. Matt Kaeberlein, one of the world’s leading aging scientists, breaks down the truth about biological age, longevity, mTOR, rapamycin, GLP-1s, supplements, peptides, and the Dog Aging Project. You’ll learn why exercise, sleep, nutrition, and social connection are the biggest levers for healthspan, what the science really says about calorie restriction, and how to spot the difference between evidence-based longevity strategies and industry hype. If you care about anti-aging, healthy aging, longevity science, and living longer better, this conversation gives you the clearest roadmap yet. Guest : @mkaeberlein SUBSCRIBE @Dr_SMiT For More Insightful Videos ! DrSMiT.oia.bio/TheDrSMiTShow Why You're Aging Faster Than You Should (And How to Stop It) Why You're Aging Faster Than You Believe (And How to Stop It) The #1 Longevity Mistake You're Making ( & How to FIX IT ) The Truth About Biological Age, Longevity, and Anti-Aging Science | Matt Kaeberlein World's Top Longevity Scientist's Health Span SECRETS The Longevity SECRETS Experts Don't Want You to Know What the World's Top Longevity Scientist Told Me About Aging World's Top Longevity Scientist Reveals Anti-Aging SECRETS The SECRET to a Longer, Healthier Life (Top Longevity Scientist Explains) Chapters : 00:00:00 - Teaser & Podcast Highlights 00:01:10 - Rapid-Fire Supplement & Modality Rating 00:03:32 - Announcement & Context 00:04:51 - Introduction to Dr. Matt Kaeberlein 00:06:31 - Biological vs. Chronological Age & First Principles 00:10:02 - Evolutionary Biology & The Hallmarks of Aging 00:14:34 - Does Biological Aging Drive Chronic Disease? 00:17:21 - Reactive Care vs. Proactive Longevity Medicine 00:19:58 - The "50-Year Stagnation" Myth & Lifespan Limits 00:23:58 - Translating Animal Models to Humans 00:27:54 - The Dog Aging Project: Translational Bridge for Human Aging 00:32:20 - IGF-1, Body Size & Lifespan (Dog Breeds & Laron Syndrome) 00:37:32 - What is mTOR? The Master Cellular Nutrient Sensor 00:41:00 - How mTOR Regulation Shifts Across the Lifespan 00:44:27 - Lifestyle Pillars: Diet Quality vs. Quantity vs. Timing 00:48:52 - The Protein Debate: RDA, Optimal Intake & Misconceptions 00:51:36 - High Protein vs. Resistance Training vs. Rapamycin 00:56:05 - Human Rapamycin Data on Muscle Mass & Sarcopenia 01:00:33 - Calorie Restriction: Lab Rodents vs. Human Sustainability 01:06:05 - GLP-1 Agonists: Microdosing, Longevity & Preserving Muscle 01:10:36 - Exercise Physiology: VO2 Max & Anti-Aging Mechanisms 01:14:20 - Sleep: Circadian Biology & Glymphatic Clearance 01:17:38 - Essential Diagnostics: Blood Biomarkers, DEXA & LinAge 2 01:23:57 - Advanced Screening: CCTA Heart Scans & Galleri Test 01:28:46 - Whole-Body MRI: Benefits & Managing False Positives 01:33:51 - Cutting Through Hype: Peptides, Supplements & Risk-Reward #Longevity #AntiAging #Healthspan #AgingScience #BiologicalAging #mTOR #Rapamycin #GLP1 #CaloricRestriction #Exercise #Sleep #Biohacking #DogAgingProject #Supplements #Peptides #Diagnostics #HealthOptimization #HealthyAging #EvidenceBasedMedicine #MattKaeberlein