Episode 5 - Drivers of Metabolism | Sue Anne Part-1

In this episode, we’re joined by Dr. Sue Anne Toh, Co-Founder and Director of NOVI, for an insightful discussion on metabolism. We explore key aspects of metabolism, including the roles of organs, hormones, metabolic rate, and metabolic health. Dr. Toh also highlights the distinct metabolic traits seen in Indian and broader Asian populations, emphasizing the importance of studying and understanding our own population for more effective health strategies. Time stamp: 00:00 - Introduction 01:39 - Introduction Sue Anne Toh 04:44 - Mitochondria – hub of metabolism 09:16 - Is mitochondria making us age ? Function of mitochondria 13:05 - Different fuel different effect- depend on the whole being 16:25 - Regulatory mechanisms and organs involved in metabolic control 20:30 - Signs of metabolic dysfunction 24:47 - Metabolic rate 35:07 - BMI of south Asian Population 37:26 - Skinny fat 38:31 - South-east Asians need to work harder to keep metabolically fit 45:00 - Summary and closing The Guest: Dr. Sue Anne Toh is the Co-Founder, CEO and Medical Director of NOVI. She is also Adjunct Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore. Dr. Toh is a specialist in internal medicine, diabetes, endocrinology, and metabolism, with expertise in health systems, value-based healthcare, evidence-based wellness, integrated health services development, delivery, and evaluation. Connect with Dr. Sue Anne Toh: https://novi-health.com/ , https://www.linkedin.com/in/sue-anne-toh-4225897/ References: 1.Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780. PMID: 19357406; PMCID: PMC2859951. 2.Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity. Nutr J. 2016 Dec 1;15(1):100. doi: 10.1186/s12937-016-0219-0. PMID: 27903298; PMCID: PMC5131405. 3.Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility. Nutr Metab (Lond). 2016 Oct 27;13:74. doi: 10.1186/s12986-016-0135-5. PMID: 27800008; PMCID: PMC5081666. Parvaresh Rizi E, Loh TP, Baig S, Chhay V, Huang S, Caleb Quek J, Tai ES, Toh SA, Khoo CM. A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men. PLoS One. 2018 Jan 31;13(1):e0191609. doi: 10.1371/journal.pone.0191609. PMID: 29385178; PMCID: PMC5792004. About Biopeak: Biopeak is a deep science-led longevity organization focused on personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer, but live without limits. Biopeak. Decode your path to Limitless Living. Follow Us: Longevity India: https://www.longevity.iisc.ac.in/ Biopeak: https://www.biopeak.com/ LinkedIn: https://www.linkedin.com/company/longevity-india-iisc/ Instagram: https://www.instagram.com/longevity_iisc/ Spotify: https://open.spotify.com/show/0NXTdG0fBIfmKIHV2vkxbV Disclaimers: The content shared on the Biopeak Live podcast is intended for general educational purposes only and should not be considered as medical advice. We strongly recommend consulting a licensed healthcare professional for any health-related concerns, especially before making any lifestyle, dietary, or medical changes based on the content provided in this podcast.