Why We Age - And What We Can Do About It | Brian Kennedy | Peter Attia Podcast

Want to support the channel? Become a member to get early access to our videos, watch member-only videos and request summaries of podcasts of your choice! https://www.youtube.com/channel/UClk1399isACmkiswDijHC6g/join In this podcast episode, Brian Kennedy explores the complex biology of aging, emphasizing the need for mathematical models grounded in physical principles to move beyond descriptive approaches. He critiques the "hallmarks of aging" framework, proposing that aging results from a decline in the body's homeostatic network and resilience. Chronic inflammation and dysregulation of the mTOR pathway are highlighted as central factors, with rapamycin discussed as a promising but limited geroprotective drug. Kennedy also reviews biological clocks, emerging interventions like alpha-ketoglutarate, and the challenges of translating animal research to humans. He stresses the importance of lifestyle factors, conventional medicine, and cautious combination of therapies. Finally, he addresses the potential and risks of advanced technologies such as gene therapy and AI in aging research, advocating for rigorous trials and careful integration of new tools. 00:00 Introduction 01:26 The Role of Inflammation and mTOR in Aging 02:56 Models of Aging and the “Slope” of Lifespan 04:06 Rapamycin: Potential and Limitations 05:15 Biological Clocks and Measuring Aging 06:30 Alpha-Ketoglutarate and Other Emerging Interventions 07:37 The Challenge of Translating Animal Research to Humans 08:39 The Role of Lifestyle and Conventional Medicine 09:44 The Complexity of Combining Interventions 10:39 The Promise and Perils of Emerging Technologies This video is a podcast summary of The Peter Attia Drive Podcast episode titled '357 ‒ A new era of longevity science: models of aging, rapamycin trials, biological clocks, & more'. Link: https://youtu.be/7yNvz_0Q1eQ Publish date: Jul 21, 2025 Summary article: https://podmarized.com/episodes/the-peter-attia-drive-podcast/357-a-new-era-of-longevity-science-models-of-aging-rapamycin-trials-biological-clocks-more 💌 Daily Podcast Knowledge Delivered Into Your Inbox: https://podcastnuggets.substack.com #briankennedy #thepeterattiadrivepodcast #longevity #aging